Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPTODA-OTI, Karla SawadaSTEFANO, Jose TadeuCAVALEIRO, Ana MercedesCARRILHO, Flair JoseCORREA-GIANELLA, Maria LuciaOLIVEIRA, Claudia Pinto Marques de Souza de2023-12-152023-12-152022METABOLIC SYNDROME AND RELATED DISORDERS, v.20, n.2, p.114-123, 20221540-4196https://observatorio.fm.usp.br/handle/OPI/57430Background: We investigated the possible association of uncoupling protein 3 gene (UCP3) single nucleotide polymorphisms (SNPs) with nonalcoholic steatohepatitis (NASH) and metabolic syndrome (MetS) in nonalcoholic fatty liver disease (NAFLD) Brazilian patients.Methods: UCP3 SNPs rs1726745, rs3781907, and rs11235972 were genotyped in 158 biopsy-proven NAFLD Brazilian patients. Statistics was performed with JMP, R, and SHEsis softwares.Results: The TT genotype of rs1726745 was associated with less occurrence of MetS (P = 0.006) and with lower body mass index (BMI) in the entire NAFLD sample (P = 0.01) and in the NASH group (P = 0.02). The rs1726745-T was associated with lower values of AST (P = 0.001), ALT (P = 0.0002), triglycerides (P = 0.01), and total cholesterol (P = 0.02) in the entire NAFLD sample. Between groups, there were lower values of aminotransferases strictly in individuals with NASH (AST, P = 0.002; ALT, P = 0.0007) and with MetS (AST, P = 0.002; ALT, P = 0.001). The rs3781907-G was associated with lower GGT elevation values in the entire NAFLD sample (P = 0.002), in the NASH group (P = 0.004), and with MetS group (P = 0.003) and with protection for advanced fibrosis (P = 0.01). The rs11235972-A was associated with lower GGT values in the entire NAFLD sample (P = 0.006) and in the NASH group (P = 0.01) and with MetS group (P = 0.005), with fibrosis absence (P = 0.01) and protection for advanced fibrosis (P = 0.01). The TAA haplotype was protective for NASH (P = 0.002), and TGG haplotype was protective for MetS (P = 0.01).Conclusion: UCP3 gene variants were associated with protection against NASH and MetS, in addition to lower values of liver enzymes, lipid profile, BMI and, lesser fibrosis severity in the studied population.engrestrictedAccessUCP3single nucleotide polymorphismnonalcoholic fatty liver diseasenonalcoholic steatohepatitismetabolic syndromegamma-glutamyl-transferaseuncoupling protein-3 geneinsulin-resistanceoxidative stressobesityprogressiontranspeptidaseepidemiologycholesterolprevalencearticleCopyright MARY ANN LIEBERT, INC10.1089/met.2020.0104Medicine, Research & Experimental1557-8518