Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPCORBIERE, Pauline deRITZEL, KatrinCAZABAT, LaureROPERS, JacquesSCHOTT, MatthiasLIBE, RosellaKOSCHKER, Ann-CathrinLEBOULLEUX, SophieDEUTSCHBEIN, TimoCAO, Christine DoHAHNER, StefanieDRUI, DelphineMIEHLE, KonstanzeCARON, PhilippeWALDMANN, JensCHABRE, OlivierQUINKLER, MarcusTOURAINE, PhilippeFRAGOSO, Maria C. VillaresBERTHERAT, JeromeBERTAGNA, XavierFASSNACHT, MartinRAFFIN-SANSON, Marie-Laure2016-03-142016-03-142015JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.100, n.12, p.4604-4611, 20150021-972Xhttps://observatorio.fm.usp.br/handle/OPI/13567Context: Adrenocortical carcinomas (ACCs) are rare, aggressive tumors, of which some express receptors for estradiol, progesterone, and/or human chorionic gonadotoropin. Because this disease is encountered frequently in young women, pregnancy is a relevant issue. Objective: to evaluate the impact of pregnancy on outcome of patients previously treated for ACC. Design/Setting: retrospective observational multicenter study of the European Network for the Study of Adrenal Tumors. Patients: Seventeen ACC patients (21 pregnancies), becoming pregnant at least 3 months after the initial treatment, were compared with 247 nonpregnant ACC patients less than 47 years old. A control group of 34 patients matched for age, sex, and tumor stage was used for survival analysis. Main Outcome Measure(s): Overall survival, tumors characteristics at diagnosis, pregnancy outcome. Results: All 17 patients with pregnancies had localized ACC. The median time between surgery and conception was 4 years (0.3-12 y). Two pregnancies were terminated at 8 weeks. Sixteen women gave birth to 19 live infants. With exception of 1 (presumably unrelated) cardiac malformation, no severe fetal or maternal complication was observed. After a median follow-up time of 8.36 years and 5.26 years after the first conception, 1 of the 17 patients had died and 5 had experienced a recurrence, among whom 3 occurred before conception. Overall survival was not significantly different between the ""pregnancy group"" and the matched controls. Conclusion: Pregnancy in patients previously treated forACCseems to not be associated with worse clinical outcome, although a ""healthy mother effect"" cannot be excluded.engrestrictedAccesscushings-syndromebreast-canceradrenal carcinomaexpressionreceptorsurvivalmitotanetumorigenesismetaanalysisprognosisarticleCopyright ENDOCRINE SOC10.1210/jc.2015-2341Endocrinology & Metabolism1945-7197