Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPGREVE, Julia Maria D'AndreaBRECH, Guilherme CarlosQUINTANA, MariliaSOARES, Andre Luiz de SeixasALONSO, Angelica Castilho2020-10-152020-10-152020REVISTA BRASILEIRA DE MEDICINA DO ESPORTE, v.26, n.4, p.285-288, 20201517-8692https://observatorio.fm.usp.br/handle/OPI/37829The new coronavirus, which causes the infectious disease named COVID-19 by the World Health Organization (WHO), was notified in 2020 in China. The main clinical manifestations in infected patients are fever, cough and dyspnoea. These patients are prone to developing cardiac changes, diffuse myopathy, decreased pulmonary function, decreased inspiratory muscle strength, and a deterioration in functional capacity. Thus, it is expected that patients affected by COVID-19 will suffer musculoskeletal consequences as a result of the inflammatory process and loss of muscle mass caused by immobility, generating motor incapacities that are not yet quantifiable. It is important to understand the clinical implications caused by COVID-19, in order to have better rehabilitation strategies for these patients. The aim of this study was to conduct a reflective analysis of the impact of COVID-19 on the immune, neuromuscular and musculoskeletal systems, and its rehabilitation process. This is a reflexive analysis, developed in the Laboratory for the Study of Movement of the Institute of Orthopaedics' and Traumatology, at the Universidade de Sao Paulo School of Medicine, SP, Brazil. In this analysis, we reflect on the following topics related to COVID-19: immunological mechanisms, impact on the neuromuscular and musculoskeletal systems, and the rehabilitation of patients.engopenAccessCOVID-19Neuromuscular manifestationsMusculoskeletal systemExercise therapyImmune systeminfluenza-a viruscoronavirus infectionmusclerecoverycareicuarticleCopyright SOC BRASILEIRA MED ESPORTE10.1590/1517-869220202604ESP002PhysiologySport Sciences1806-9940