Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSTEFANO, Jose TadeuDUARTE, Sebastiao Mauro BezerraALTIKES, Renato Gama Ribeiro LeiteOLIVEIRA, Claudia P. P.2023-04-142023-04-142023THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM, v.14, article ID 20420188231160300, 17p, 20232042-0188https://observatorio.fm.usp.br/handle/OPI/52946Lifestyle changes should be the main basis for any treatment for metabolic dysfunction-associated fatty liver disease (MAFLD), aiming to increase energy expenditure, reduce energy intake and improve the quality of nutrients consumed. As it is a multifactorial disease, approaches such as physical exercise, a better dietary pattern, and possible pharmacological intervention are shown to be more efficient when used simultaneously to the detriment of their applications. The main treatment for MAFLD is a lifestyle change consisting of diet, activity, exercise, and weight loss. The variables for training prescription such as type of physical exercise (aerobic or strength training), the weekly frequency, and the intensity most indicated for the treatment of MAFLD remain uncertain, that is, the recommendations must be adapted to the clinical conditions comorbidities, and preferences of each subject in a way individual. This review addresses recent management options for MAFLD including diet, nutrients, gut microbiota, and physical exercise.engopenAccessdietary patternlifestyle changesmetabolic dysfunction-associated fatty liver disease (MAFLD)nonalcoholic fatty liver disease (NAFLD)physical exercisefatty-liver-diseasecardiovascular risk-factorscardiac autonomic controllife-stylenonalcoholic steatohepatitismediterranean dietinsulin-resistancemetabolic syndromepostmenopausal womenphysical-activityarticleCopyright SAGE PUBLICATIONS LTD10.1177/20420188231160394Endocrinology & Metabolism2042-0196