Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPPASCHOAL, Eric Homero AlbuquerqueYAMAKI, Vitor NagaiTEIXEIRA, Renan Kleber CostaPASCHOAL JUNIOR, Fernando MendesJONG-A-LIEM, Glaucia SuzannaTEIXEIRA, Manoel JacobsenYAMADA, Elizabeth SumiRIBEIRO-DOS-SANTOS, AndreaBOR-SENG-SHU, Edson2018-02-022018-02-022018NEUROSURGICAL REVIEW, v.41, n.1, p.87-94, 20180344-5607https://observatorio.fm.usp.br/handle/OPI/24923The aneurysmal subarachnoid hemorrhage is a major public health problem described as a sudden drastic event with no warning symptoms and high morbidity and mortality rates. The role of the endothelial isoform of nitric oxide synthase gene polymorphism in intracranial aneurysms (IAs) is still a matter of controversy with divergent findings among European, American, and Asian populations. Our study purposed to test the association between intracranial aneurysms formation and nitric oxide gene polymorphisms through a systematic review and meta-analysis. Systematic search on Medline, Lilacs, and EMBASE was performed. The primary search resulted in 139 papers, out of which 9 met our inclusion criteria after a full text analysis. The dominant T786C model found a significant association with IA (OR 1.22, 95 % CI 1.04-1.44, p = 0.01), so did studies of the recessive T786C model (OR 0.37, 95 % CI 0.30-0.45, p < 0.0001) but with opposite effect. Our findings support the presence of the T786C polymorphism as a predictor for the development of intracranial aneurysm in the cerebral vascular system. More studies are necessary in order to elucidate the pathways of the endothelial nitric oxide synthase (eNOS) in cerebrovascular diseases and in defining how different allelic combinations of the eNOS gene single-nucleotide polymorphism (SNP) could favor this pathological process.engrestrictedAccessEndothelial nitric oxide synthaseGenetic polymorphismsIntracranial aneurysmsMeta-analysisSubarachnoid hemorrhagesingle-nucleotide polymorphismsubarachnoid hemorrhagecerebral vasospasmgene polymorphismsaortic-aneurysmrisk-factordiseaseatherosclerosisrupturesizearticleCopyright SPRINGER10.1007/s10143-016-0761-4Clinical NeurologySurgery1437-2320