New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Coinfected Patients

Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPPAPOTTO, Pedro HenriqueMAEDA, SolangeTOMIMORI, JaneXAVIER, Marilia BrasilRIZZO, Luiz VicenteKALLAS, Esper GeorgesCARVALHO, Karina Inacio2015-12-102015-12-102015PLOS NEGLECTED TROPICAL DISEASES, v.9, n.9, article ID e0004030, 8p, 20151935-2735https://observatorio.fm.usp.br/handle/OPI/12310Leprosy control is achieved through a fine-tuning of T(H)1 and T(H)2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.engopenAccesst-cellsleprosyNew Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Coinfected PatientsarticleCopyright PUBLIC LIBRARY SCIENCE10.1371/journal.pntd.0004030Infectious DiseasesParasitologyTropical Medicine