Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPLUGLIO, MicheleMARQUES, Tatiana de Carvalho SilvaPEREIRA, Maria Fernanda BadueDELGADO, Artur FigueiredoCARVALHO, Werther Brunow deTANNURI, Ana Cristina AounSANDY, Natascha SilvaLITVINOV, NadiaPAULA, Camila Sanson Yoshino deSANTOS, Ariane Guissi dosLAZARI, Carolina dos SantosGOUVEA, Michele Soares GomesPAULA, Anderson Vicente deMENDOZA, Tania Regina TozettoTANIGAWAH, Ryan YukimatsuLIMAH, Fabiana RobertoHIRAYAMAH, Andre BubnaSANTOS, Isabela Gusson Galdino dosPINHOG, Joao Renato RebelloSABINOG, Ester CerdeiraMENDES-CORREAHG, Maria CassiaALVESH, Venancio Avancini FerreiraMARQUESC, Heloisa Helena de Sousa2024-02-152024-02-152023TRANSPLANTATION PROCEEDINGS, v.55, n.9, 20230041-1345https://observatorio.fm.usp.br/handle/OPI/57989A new outbreak of hepatitis of unknown origin raised awareness in the international community. A few reports have attempted to associate new cases with adenovirus infection and the immunologic effects of previous SARS-CoV-2 infections through a superantigen mechanism. Moreover, according to a case series, viral isolates were identified in 7 of 10 cases of pediatric patients with hepatitis of unknown origin and acute liver failure. Adenovirus was detected by respiratory secretion polymerase chain reaction in 2 patients, with neither presenting with SARS-CoV-2 acute infection. Clinical and laboratory descriptions and cross-referencing epidemiologic and pathophysiological data can help identify possible disease etiologies.engrestrictedAccesshepatitisarticleCopyright ELSEVIER SCIENCE INC10.1016/j.transproceed.2023.08.004ImmunologySurgeryTransplantation1873-2623