Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSTEINER, JohannSCHMITT, AndreaSCHROETER, Matthias L.BOGERTS, BernhardFALKAI, PeterTURCK, Christoph W.MARTINS-DE-SOUZA, Daniel2015-02-062015-02-062014EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.264, n.4, p.311-316, 20140940-1334https://observatorio.fm.usp.br/handle/OPI/8797Here we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology.engrestrictedAccessS100BCorpus callosumWhite matterOligodendrocytesProteomicsMass spectrometryserum-levelsbraingliacellsarticleCopyright SPRINGER HEIDELBERG10.1007/s00406-014-0490-zClinical NeurologyPsychiatry1433-8491