Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPKAMAMOTO, FabioLIMA, Ana Lucia MunhozREZENDE, Marcelo Rosa deMATTAR-JUNIOR, RamesLEONHARDT, Marcos de CamargoKOJIMA, Kodi EdsonSANTOS, Carla Chineze dos2018-03-062018-03-062017CLINICS, v.72, n.12, p.737-742, 20171807-5932https://observatorio.fm.usp.br/handle/OPI/25629OBJECTIVES: Negative-pressure wound therapy has been widely adopted to reduce the complexity of treating a broad range of acute and chronic wounds. However, its cost is high. The objective of this study was to evaluate the following two different methods of negative-pressure wound therapy in terms of healing time: a low-cost method of negative-pressure wound therapy (a pressure stabilizer device connected to a hospital wall-vacuum system with a gauze-sealed dressing, USP) and the standard of care (vacuum-assisted closure, VAC). METHODS: This is a randomized, controlled, non-inferiority, unblinded trial. Patients admitted with complex injuries to a trauma center in a public referral hospital who were indicated for orthopedic surgery were randomized to a USP or VAC group. The primary outcome was the time required to achieve a ""ready for surgery condition'', which was defined as a wound bed with healthy granulation tissue and without necrosis or purulent secretion. Wound bed area contraction, granulation tissue growth and the direct costs of the dressings were secondary outcomes. RESULTS: Variation in area and granulation tissue growth were essentially the same between the systems, and healing time was equal between the groups (p= 0.379). In both systems, serial debridement increased wound area (p= 0.934), and granulation tissue was also increased (p= 0.408). The mean treatment cost was US$ 15.15 in the USP group and US$ 872.59 in the VAC group. CONCLUSIONS: For treating complex traumatic injuries, USP was non-inferior to and less expensive than VAC.engopenAccessNegative-Pressure Wound TherapyWound HealingWounds and InjuriesCost Savingsvacuum-assisted closureclinical-evaluationarticleCopyright HOSPITAL CLINICAS, UNIV SAO PAULO10.6061/clinics/2017(12)04Medicine, General & Internal1980-5322