Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPGOYA, Thiago T.SILVA, Rosyvaldo F.GUERRA, Renan S.LIMA, Marta F.BARBOSA, Eline R. F.CUNHA, Paulo JannuzziLOBO, Denise M. L.BUCHPIGUEL, Carlos A.BUSATTO-FILHO, GeraldoNEGRAO, Carlos E.LORENZI-FILHO, GeraldoUENO-PARDI, Linda M.2016-03-142016-03-142016SLEEP, v.39, n.1, p.25-33, 20160161-8105https://observatorio.fm.usp.br/handle/OPI/13423Study Objectives: To investigate muscle sympathetic nerve activity (MSNA) response and executive performance during mental stress in obstructive sleep apnea (OSA). Methods: Individuals with no other comorbidities (age = 52 +/- 1 y, body mass index = 29 +/- 0.4, kg/m(2)) were divided into two groups: (1) control (n = 15) and (2) untreated OSA (n = 20) defined by polysomnography. Mini-Mental State of Examination (MMSE) and Inteligence quocient (IQ) were assessed. Heart rate (HR), blood pressure (BP), and MSNA (microneurography) were measured at baseline and during 3 min of the Stroop Color Word Test (SCWT). Sustained attention and inhibitory control were assessed by the number of correct answers and errors during SCWT. Results: Control and OSA groups (apnea-hypopnea index, AHI = 8 +/- 1 and 47 +/- 1 events/h, respectively) were similar in age, MMSE, and IQ. Baseline HR and BP were similar and increased similarly during SCWT in control and OSA groups. In contrast, baseline MSNA was higher in OSA compared to controls. Moreover, MSNA significantly increased in the third minute of SCWT in OSA, but remained unchanged in controls (P < 0.05). The number of correct answers was lower and the number of errors was significantly higher during the second and third minutes of SCWT in the OSA group (P < 0.05). There was a significant correlation (P < 0.01) between the number of errors in the third minute of SCWT with AHI (r = 0.59), arousal index (r = 0.55), and minimum O-2 saturation (r = -0.57). Conclusions: As compared to controls, MSNA is increased in patients with OSA at rest, and further significant MSNA increments and worse executive performance are seen during mental stress.engrestrictedAccessexecutive performancemental stressmuscle sympathetic nerve activityobstructive sleep apneaadvanced heart-failureacute mental stressblood-pressurecardiovascular-responsesneurovascular responsesobese womenhypertensionhumansrisktaskarticleCopyright AMER ACAD SLEEP MEDICINE10.5665/sleep.5310Clinical NeurologyNeurosciences1550-9109