Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPASTOLFI, Rafael HaddadBUGANO, Diogo Diniz GomesFRANCISCO, Alice Aparecida Rodrigues FerreiraSOUZA, Marcelo Moreira Tavares deONO-NITA, Suzane KiokoBARACAT, Edmund Chada2017-11-272017-11-272011MEDICAL HYPOTHESES, v.77, n.2, p.162-164, 20110306-9877https://observatorio.fm.usp.br/handle/OPI/23005Patients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.engrestrictedAccessudp-glucuronosyltransferasegenetic polymorphismspostmenopausal womenendogenous estrogensbilirubin metabolismreceptor statusugt1a1phenotypesarticleCopyright CHURCHILL LIVINGSTONE10.1016/j.mehy.2011.03.047Medicine, Research & Experimental