Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPV, D. Rojas MejiaZWIENER, R. D.VILLA, R. CardonaRAMIREZ, L. F.ESPINOSA, D. L. SilvaZANACCHI, V. A.SOSA, P. PirainoENSINA, L. F.BIANCHI, P. GiavinaPORTILHO, N. CoelhoAUN, M. VivoloBENAVIDES, E. MatosRUIZ, D. M. MartinezJARES, E.REYES, C. D. Serrano2024-02-152024-02-152021JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, v.31, n.4, p.322-331, 20211018-9068https://observatorio.fm.usp.br/handle/OPI/57866Background: Severe cutaneous adverse reactions to drugs (SCARs) are associated with high morbidity and mortality and with sequelae. Objective: To characterize patients with SCARs in 8 health care institutions in Latin America. Methods: We performed a cross-sectional, descriptive, multicenter study of patients diagnosed with SCARs in Latin America between January 2009 and December 2018. The analysis was carried out using a database in BD Clinic. Results: We collected 70 patients, of whom 42 (60%) were women. Mean age was 38.7 years. Forty-two patients (60%) had DRESS-DIHS, 12 (17.1%) TEN, 5 (7.1%) SJS, 6 (8.5%) AGEP, 4 (5.7%) other reactions not classified as SCARs, and 1 (1.4%) overlapping SJS-TEN. The main causative drugs were aromatic anticonvulsants in 31 cases (44.3%), beta-lactam antibiotics in 11 cases (15.7%), and non-beta-lactam antibiotics in 6 cases (8.6%). In all of the cases, the suspected drug was withdrawn at the first sign of a SCAR. Sixty-six patients (94.2%) received anti-inflammatory treatment, mostly systemic corticosteroids. Complications occurred in 53 cases (75.7%), and 3 patients died (4.3%). Thirteen patients (18.6%) had sequelae. Conclusions: This is the first multicenter report on SCARs in Latin America. DRESS-DIHS was the most frequently reported clinical entity, and anticonvulsants were the main triggers. Most of the patients received systemic corticosteroids. Complications were frequent, and 3 patients died.engopenAccessDrug eruptionsStevens-Johnson syndromeToxic epidermal necrolysisDRESSAcute generalized exanthematous pustulosisLatin Americatoxic epidermal necrolysisstevens-johnson-syndromegeneralized exanthematous pustulosissystemic symptoms dressintravenous immunoglobulinantiepileptic drugspediatric-patientsburn uniteosinophiliahypersensitivityarticleCopyright ESMON PUBLICIDAD S A, DEPT ALLERGY & CLIN IMMUNOL, CLIN UNIV NAVARRA10.18176/jiaci.0497AllergyImmunology1698-0808