Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPKAHALEH, MichelBHAGAT, VickyDELLATORE, PeterTYBERG, AmySARKAR, AvikSHAHID, Haroon M.ANDALIB, ImanALKHIARI, ResheedGAIDHANE, MonicaKEDIA, PrashantNIETO, JoseKUMTA, Nikhil A.DIXON, Rebekah E.SALAMEH, HabeebMAVROGENIS, GeorgiosBASSIOUKAS, StefanosABE, SeiichiroARENTES, Vitor N.MORITA, Flavio H.SAKAI, PauloMOURA, Eduardo G. de2022-12-212022-12-212022ENDOSCOPY INTERNATIONAL OPEN, v.10, n.11, p.E1491-E1496, 20222364-3722https://observatorio.fm.usp.br/handle/OPI/50520Background and study aims Endoscopic techniques are rapidly emerging for resection of subepithelial tumors (SETs). Submucosal tunneling for endoscopic resection (STER), endoscopic full-thickness resection (EFTR) and laparoscopic endoscopic cooperative surgery (LECS) are current alternatives to open surgery. In this study, we aimed to compare the three endoscopic techniques. Patients and methods Consecutive patients who underwent resection of a submucosal esophageal or gastric lesion at several tertiary care centers were included in a dedicated registry over 3 years. Demographics, size and location of resected lesion, histology of specimen, length of procedure, adverse events (AEs), duration of hospital stay, and follow-up data were collected. Results Ninety-six patients were included (47.7 % male, mean age 62): STER n = 34, EFTR n = 34, LECS n = 280. The lesions included leiomyoma, gastrointestinal stromal tumors (GISTs) and other. The mean lesion size was 28 mm (STD 16, range 20-72 mm). The majority of lesions in the EFTR and laparoscopic-assisted resection group were GISTs. There was no significant difference in clear resection margins, post-procedure complication rates, recurrence rate and total follow-up duration between the groups. However, the LECS group had a procedure time at least 30 minutes longer than STER or EFTR ( P < 0.01). Total hospital stay for the laparoscopic-assisted resection group was also longer when compared to STER (1.5) and EFTR (1.8) ( P < 0.01). Conclusions STER, EFTR, and laparoscopic-assisted resection are efficacious approaches for resection of SETs with similar R0 resection rates, complication rates, and AE rates. Laparoscopic assisted resection appears more time-consuming and is associated with a longer hospital stay.engopenAccessmuscularis propria layerdissectionclosurediagnosisbenigncliparticleCopyright GEORG THIEME VERLAG KG10.1055/a-1922-7890Gastroenterology & HepatologySurgery2196-9736