Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPPRADO, Danilo M.GUALANO, BrunoPINTO, Ana Lucia S.SALLUM, Adriana M.PERONDI, Maria B.ROSCHEL, HamiltonSILVA, Clovis Artur2017-11-272017-11-272011MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v.43, n.12, p.2221-2223, 20110195-9131https://observatorio.fm.usp.br/handle/OPI/23637PRADO, D. M., B. GUALANO, A. L. S. PINTO, A. M. SALLUM, M. B. PERONDI, H. ROSCHEL, and C. A. SILVA. Exercise in a Child with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. Med. Sci. Sports Exerc., Vol. 43, No. 12, pp. 2221-2223, 2011. Exercise training has emerged as a potential therapeutic strategy to counteract the decline in physical function and aerobic capacity in pediatric rheumatic disease. Purpose: We report for the first time on the effects of exercise training in juvenile systemic lupus erythematosus (JSLE) and antiphospholipid syndrome (APS). Methods: A 15-yr-old boy with JSLE and APS treated with warfarin, azathioprine, and prednisone underwent a 12-wk aerobic exercise training program to improve his physical capacity and functioning. Before and after the 12-wk exercise program, the patient was submitted to incremental cardiopulmonary tests to determine (V) over dotO(2peak), peak and submaximal exercise intensity, and time to exhaustion. In addition, a 6-min square-wave test was performed for assessing metabolic parameters. Functioning was assessed by using the visual analog scale. Laboratory parameters of inflammation were also assessed at baseline and 48 h after the last training session. Results: All the cardiopulmonary parameters (e. g., (V) over dotO(2max) = +36.0%, time to exhaustion = +67.8%, peak exercise intensity = +16.7%) and the metabolic cost of movement (e. g., energy expenditure = -28.3% to -33.3%, (V) over dotO(2) = -29.3% to -33.4%) were improved. Both disease activity and cumulative damage scores did not change after the intervention, and no evidence of exercise-induced exacerbation of inflammation was observed. Visual analog scale scores were also improved according to the patients' evaluation (before intervention = 8 vs after intervention = 10), parents' evaluation (before intervention = 8 vs after intervention = 10), and physicians' evaluation (before intervention = 6 vs after intervention = 9). Conclusions: This is the first evidence that a 12-wk supervised aerobic training program can be safe and effective in improving aerobic conditioning and physical function in a patient with JSLE and APS. In light of these findings, the therapeutic effects of exercise training in pediatric rheumatic diseases merit further investigations.engrestrictedAccessAEROBIC TRAININGJUVENILE SYSTEMIC LUPUS ERYTHEMATOSUSTHERAPEUTIC EFFECTSPEDIATRIC RHEUMATIC DISEASESclassificationcriteriafitnesstrialarticleCopyright LIPPINCOTT WILLIAMS & WILKINS10.1249/MSS.0b013e318223b177Sport Sciences