Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPMANFRO, Arthur GusPINE, Daniel S.POLANCZYK, Guilherme VanoniSANTORO, MarcosSMOLLER, Jordan WassertheilKOENEN, KarestanMARI, JairPAN, Pedro MarioZUGMAN, AndreSCHAFER, Julia LuizaBELANGERO, SintiaGOSMANN, Natan PereiraSIMIONI, Andre RafaelHOEXTER, Marcelo QueirozMIGUEL, Euripedes ConstantinoGADELHA, AryROHDE, Luis AugustoSALUM, Giovanni Abrahao2022-02-242022-02-242021JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v.60, n.12, p.1501-1512, 20210890-8567https://observatorio.fm.usp.br/handle/OPI/44554Objective: It is unclear if pediatric executive dysfunction assessed only with cognitive tasks predicts clinically relevant outcomes independently of psychiatric diagnoses. This study tested the stability and validity of a task-based classification of executive function. Method: A total of 2,207 individuals (6-17 years old) from the Brazilian High-Risk Cohort Study participated in this study (1,930 at baseline, 1,532 at follow-up). Executive function was measured using tests of working memory and inhibitory control. Dichotomized age-and sex-standardized performances were used as input in latent class analysis and receiver operating curves to create an executive dysfunction classification (EDC). The study tested EDC's stability over time, association with symptoms, functional impairment, a polymorphism in the CADM2 gene, polygenic risk scores (PRS), and brain structure. Analyses covaried for age, sex, social class, IQ, and psychiatric diagnoses. Results: EDC at baseline predicted itself at follow-up (odds ratio [OR] = 5.11; 95% CI 3.41-7.64). Participants in the EDC reported symptoms spanning several domains of psychopathology and exhibited impairment in multiple settings, including more adverse school events (OR = 2.530; 95% CI 1.838-3.483). Children in the EDC presented higher attention-deficit/hyperactivity disorder and lower educational attainment PRS at baseline; higher schizophrenia PRS at follow-up; and lower chances of presenting a polymorphism in a gene previously linked to high performance in executive function (CADM2 gene). They also exhibited smaller intracranial volumes and smaller bilateral cortical surface areas in several brain regions. Conclusion: Task-based executive dysfunction is associated with several validators, independently of psychiatric diagnoses and intelligence. Further refinement of task-based assessments might generate clinically useful tools.engrestrictedAccessexecutive functiongeneticsneuroimageneuropsychologyresearch domain criteriaattention-deficit/hyperactivity disorderpsychiatric-disordersworking-memoryfunction deficitsidentificationheterogeneityneuropsychologyinterventionssubtypesimpactarticleCopyright ELSEVIER SCIENCE INC10.1016/j.jaac.2020.11.016Psychology, DevelopmentalPediatricsPsychiatry1527-5418