Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPMORI, Rosana CristinaSANTOS-BEZERRA, Daniele PereiraPELAES, Tatiana SouzaADMONI, Sharon NinaPEREZ, Ricardo VessoniMONTEIRO, Maria BeatrizMACHADO, Cleide GuimaraesQUEIROZ, Marcia SilvaMACHADO, Ubiratan FabresCORREA-GIANNELLA, Maria Lucia2021-02-182021-02-182021DIABETES-METABOLISM RESEARCH AND REVIEWS, v.37, n.1, article ID e3352, 9p, 20211520-7552https://observatorio.fm.usp.br/handle/OPI/39435Background and aim 11 beta-Hydroxysteroid dehydrogenase 1 has been implicated in insulin resistance (IR) in the setting of metabolic disorders, and single nucleotide polymorphisms (SNPs) in its encoding gene (HSD11B1) have been associated with type 2 diabetes and metabolic syndrome. In type 1 diabetes (T1D), IR has been related to the development of chronic complications. We investigated the association ofHSD11B1SNPs with microvascular complications and with IR in a Brazilian cohort of T1D individuals. Materials and methods Five SNPs were genotyped in 466 T1D individuals (57% women; median of 37 years old, diabetes duration of 25 years and HbA1c of 8.4%). Results The minor allele T of rs11799643 was nominally associated with diabetic retinopathy (OR = 0.52; confidence interval [CI] 95% = 0.28-0.96;P= .036). The minor allele C of rs17389016 was nominally associated with overt diabetic kidney disease (DKD) (OR = 1.90; CI 95% = 1.07-3.37;P= .028). A follow-up study revealed that 29% of the individuals lost >= 5 mL min(-1)x 1.73 m(2)per year of the estimated glomerular filtration rate (eGFR). In these individuals (eGFR decliners), C allele of rs17389016 was more frequent than in non-decliners (OR = 2.10; CI 95% = 1.14-3.89;P= .018). Finally, minor allele T of rs846906 associated with higher prevalence of arterial hypertension, higher body mass index and waist circumference, thus conferring risk to a lower estimated glucose disposal rate, a surrogate marker of insulin sensitivity (OR = 1.23; CI 95% = 1.06-1.42;P= .004). Conclusion SNPs in theHSD11B1gene may confer susceptibility to DKD and to IR in T1D individuals.engrestrictedAccessdiabetic microvascular complicationsestimated glomerular filtration rate (eGFR)estimated glucose disposal rate (eGDR)rs17389016rs846906single nucleotide polymorphism (SNP)11-beta-hydroxysteroid dehydrogenase type-1metabolic syndromegene polymorphismsglomerular-filtrationgenomic ancestryassociationcomplicationsexpressionobesity11-beta-hsd1articleCopyright WILEY10.1002/dmrr.3352Endocrinology & Metabolism1520-7560