Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPCARRA, Fabio AlfanoMELO, Maria Edna deSTUMPF, Matheo A. M.CERCATO, CintiaFERNANDES, Ariana E.MANCINI, Marcio C.HIROTA, AdrianaKANASIRO, Alberto KendyCRESCENZI, AlessandraFERNANDES, Amanda CoelhoMIETHKE-MORAIS, AnnaBELLINTANI, Arthur PetrilloCANASIRO, Artur RibeiroCARNEIRO, Barbara VieiraZANBON, Beatriz KeikoPINHEIRO, BernardoBATISTA, Senna NogueiraNICOLAO, Bianca RuizBESEN, Bruno Adler Maccagnan PinheiroBISELLI, BrunoMACEDO, Bruno Rocha DeTOLEDO, Caio Machado Gomes DeCARVALHO, Carlos Roberto Ribeiro DeMOL, Caroline GomesSTIPANICH, CassioBUENO, Caue GasparottoGARZILLO, CibeleTANAKA, ClariceFORTE, Daniel NevesJOELSONS, DanielROBIRA, DanieleCOSTA, Eduardo Leite VieiraSILVA JUNIOR, Elson Mendes DaREGALIO, Fabiane AliottiSEGURA, Gabriela CardosoLOURO, Giulia SefrinMARCELINO, Gustavo BrasilHO, Yeh-LiFERREIRA, Isabela ArgolloGOIS, Jeison OliveiraSILVA-JR, Joao Manoel DaJUNIOR, Jose Otto ReusingRIBEIRO, Julia FrayFERREIRA, Juliana CarvalhoGALLETI, Karine VusbergSILVA, Katia ReginaISENSEE, Larissa PadraoOLIVEIRA, Larissa SantosTANIGUCHI, Leandro UtinoLETAIF, Leila SuemiLIMA, Ligia TrombettaPARK, Lucas YongsooNETTO, Lucas ChavesNOBREGA, Luciana CassimiroHADDAD, Luciana Bertocco PaivaHAJJAR, Ludhmila AbrahaoMALBOUISSON, Luiz Marcelo SaPANDOLFI, Manuela Cristina AdsuaraPARK, MarceloCARMONA, Maria Jose CarvalhoANDRADE, Maria Castilho Prandini H.SANTOS, Mariana MoreiraBATELOCHE, Matheus PereiraSUIAMA, Mayra AkimiOLIVEIRA, Mayron Faria deSOUSA, Mayson LaercioGARCIA, Michelle LouvaesHUEMER, NatassjaMENDES, Pedro VitaleLINS, Paulo Ricardo GessoloSANTOS, Pedro Gaspar DosMOREIRA, Pedro Ferreira PaivaGUAZZELLI, Renata MelloREIS, Renato Batista DosDALTRO-OLIVEIRA, RenatoROEPKE, Roberta Muriel LongoPEDRO, Rodolpho Augusto MouraKONDO, RodrigoRACHED, Samia ZahiFONSECA, Sergio Roberto Silveira DaBORGES, Thais SousaFERREIRA, ThalissaJUNIOR, Vilson CobelloSALES, Vivian Vieira TenorioFERREIRA, Willaby Serafim Cassa2024-02-152024-02-152024DIABETOLOGY & METABOLIC SYNDROME, v.16, n.1, article ID 20, 7p, 2024https://observatorio.fm.usp.br/handle/OPI/57891Background Obesity is believed to be a risk factor for COVID-19 and unfavorable outcomes, although data on this remains to be better elucidated.Objective To evaluate the impact of obesity on the endpoints of patients hospitalized due to SARS-CoV-2.Methods This retrospective cohort study evaluated patients hospitalized at a tertiary hospital (Hospital das Cl & iacute;nicas da Faculdade de Medicina da USP) from March to December 2020. Only patients positive for COVID-19 (real-time PCR or serology) were included. Data were collected from medical records and included clinical and demographic information, weight and height, SAPS-3 score, comorbidities, and patient-centered outcomes (mortality, and need for mechanical ventilation, renal replacement therapy, or vasoactive drugs). Patients were divided into categories according to their BMI (underweight, eutrophic, overweight and obesity) for comparison porpoise.Results A total of 2547 patients were included. The mean age was 60.3 years, 56.2% were men, 65.2% were white and the mean BMI was 28.1 kg/m(2). SAPS-3 score was a risk factor for all patient-centered outcomes (HR 1.032 for mortality, OR 1.03 for dialysis, OR 1.07 for vasoactive drug use, and OR 1.08 for intubation, p < 0.05). Male sex increased the risk of death (HR 1.175, p = 0.027) and dialysis (OR 1.64, p < 0.001), and underweight was protective for vasoactive drug use (OR 0.45, p = 0.027) and intubation (OR 0.31, p < 0.003).Conclusion Obesity itself was not an independent factor for worse patient-centered outcomes. Critical clinical state (indirectly evaluated by SAPS-3) appears to be the most important variable related to hard outcomes in patients infected with COVID-19.engopenAccessCOVID-19ObesityMortalityMechanical ventilationCritical caremortalityparadoxarticleCopyright BMC10.1186/s13098-023-01246-zEndocrinology & Metabolism1758-5996