Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPBIANCHI, Paulo H. M.VIERA, Lais M.GOUVEIA, Gabriela R. F. C. A.ROCHA, Andre M.BARUSELLI, Pietro S.BARACAT, Edmund C.SERAFINI, Paulo C.2015-08-142015-08-142015JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, v.32, n.4, p.543-549, 20151058-0468https://observatorio.fm.usp.br/handle/OPI/9833This study aimed to induce follicular wave emergence (FWE) using pharmacological (recombinant hCG administration) or mechanical (aspiration of dominant follicle) interventions in infertile women. Sixteen infertile women (a parts per thousand currency sign35 years) with indications for in vitro fertilization due to tubal and/or male factor infertility were randomized into three groups: control (n = 6), pharmacological (n = 5) and mechanical (n = 5) groups. Women in both experimental groups underwent serial transvaginal sonograms (TVS) from menstrual cycle day 10 until identification of a dominant follicle a parts per thousand yen15 mm. Women in the pharmacological group received 250 mu g of recombinant-hCG to induce ovulation, and resumed serial TVS 2 days later. In the mechanical group, dominant and subordinate follicles a parts per thousand yen10 mm were aspirated, and daily TVS was resumed on the following day. An increased pool of follicles a parts per thousand yen5 and a parts per thousand currency sign9 mm after interventions characterized FWE. Women in the control group underwent ovulation induction (OI) with 150 IU/day of recombinant follicle-stimulating hormone started on menstrual cycle day 3 (D3). OI was started on the day of FWE in the experimental groups. Endometrial asynchrony with development of the embryo was expected in the experimental groups. Therefore, all viable embryos were cryopreserved and transferred in an endometrial-stimulated cycle. The number of follicles a parts per thousand yen5 and a parts per thousand currency sign9 mm increased after the interventions in both experimental groups (p < .001), indicating induction of FWE. OI outcomes were similar among the groups. The pharmacological and mechanical interventions are efficient in inducing FWE; outcomes of OI synchronized with FWE should be further investigated.engrestrictedAccessAssisted reproductive treatmentOvulation inductionLuteal phaseFollicular wave emergencehuman chorionic-gonadotropingnrh antagonist protocolin-vitro fertilizationhuman menstrual-cycleovarian stimulationembryo-transferdynamicswomensuperovulationinjectionarticleCopyright SPRINGER/PLENUM PUBLISHERS10.1007/s10815-015-0432-3Genetics & HeredityObstetrics & GynecologyReproductive Biology1573-7330