Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPWEN, BoADEMI, ZanfinaWU, YaoXU, RongbinYU, PeiYE, TingtingCOELHO, Micheline de Sousa Zanotti StagliorioSALDIVA, Paulo Hilario NascimentoGUO, YumingLI, Shanshan2023-04-142023-04-142023SCIENCE OF THE TOTAL ENVIRONMENT, v.873, article ID 162368, 7p, 20230048-9697https://observatorio.fm.usp.br/handle/OPI/53077Non-optimal temperatures are associated with premature deaths globally. However, the evidence is limited in low-and middle-income countries, and the productivity losses due to non-optimal temperatures have not been quantified. We aimed to estimate the work-related impacts and economic losses attributable to non-optimal temperatures in Brazil. We col-lected daily mortality data from 510 immediate regions in Brazil during 2000 and 2019. A two-stage time-series analysis was applied to evaluate the association between non-optimum temperatures and the Productivity-Adjusted Life-Years (PALYs) lost. The temperature-PALYs association was fitted for each location in the first stage and then we applied meta -analyses to obtain the national estimations. The attributable fraction (AF) of PALY lost due to ambient temperatures and the corresponding economic costs were calculated for different subgroups of the working-age population. A total of 3,629,661 of PALYs lost were attributed to non-optimal temperatures during 2000-2019 in Brazil, corresponding to 2.90 % (95 % CI: 1.82 %, 3.95 %) of the total PALYs lost. Non-optimal temperatures have led to US$104.86 billion (95 % CI: 65.95, 142.70) of economic costs related to PALYs lost and the economic burden was more substantial in males and the population aged 15-44 years. Higher risks of extreme cold temperatures were observed in the South region in Brazil while extreme hot temperatures were observed in the Central West and Northeast regions. In conclusion, non -optimal temperatures are associated with considerable labour losses as well as economic costs in Brazil. Tailored policies and adaptation strategies should be proposed to mitigate the impacts of non-optimal temperatures on the labour supply in a changing climate.engrestrictedAccessNon-optimal temperatureProductivityEconomic costMortalitymortalityimpactburdenheatriskarticleCopyright ELSEVIER10.1016/j.scitotenv.2023.162368Environmental Sciences1879-1026