Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPRIBAS, Fernando FaglioniHUEB, WhadyREZENDE, Paulo CuryROCHITTE, Carlos EduardoNOMURA, Cesar HigaVILLA, Alexandre VolneyMORAIS, Thamara CarvalhoLIMA, Eduardo GomesBOROS, Gustavo Andre BoeingRIBEIRO, Matheus de Oliveira LaterzaLINHARES-FILHO, Jaime Paula PessoaDALLAZEN, Anderson RobertoSILVA, Rafael Rocha MolRAMIRES, Jose Antonio FranchiniKALIL-FILHO, Roberto2024-02-152024-02-152023EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, v.24, n.12, p.1700-1709, 20232047-2404https://observatorio.fm.usp.br/handle/OPI/57884Aims To analyse the association of myocardial oedema (ME), observed as high T2 signal intensity (HT2) in cardiac magnetic resonance imaging, with the release of cardiac biomarkers, ventricular ejection, and clinical outcomes after revascularization. Methods and results Patients with stable coronary artery disease with the indication for revascularization were included. Biomarker levels [troponin I (cTnI) and creatine kinase MB (CK-MB)] and T2-weighted and late gadolinium enhancement (LGE) images were obtained before and after the percutaneous or surgical revascularization procedures. The association of HT2 with the levels of biomarkers, with and without LGE, evolution of left ventricular ejection fraction (LVEF), and 5-year clinical outcomes were assessed. A total of 196 patients were divided into 2 groups: Group 1 (HT2, 40) and Group 2 (no HT2, 156). Both peak cTnI (8.9 and 1.6 ng/mL) and peak CK-MB values (44.7 and 12.1 ng/mL) were significantly higher in Group 1. Based on the presence of new LGE, patients were stratified into Groups A (no HT2/LGE, 149), B (HT2, 9), C (LGE, 7), and D (both HT2/LGE, 31). The peak cTnI and CK-MB values were 1.5 and 12.0, 5.4 and 44.7, 5.0 and 18.3, and 9.8 and 42.8 ng/mL in Groups A, B, C, and D, respectively, and were significantly different. The average LVEF decreased by 4.4% in Group 1 and increased by 2.2% in Group 2 (P = 0.057). Conclusion ME after revascularization procedures was associated with increased release of cardiac necrosis biomarkers, and a trend towards a difference in LVEF, indicating a role of ME in cardiac injury after interventions.engrestrictedAccessmyocardial oedemahigh T2 signal intensitycardiac MRIrevascularizationbiomarkersperiprocedural injuryinfarctionriskischemiasurgeryarticleCopyright OXFORD UNIV PRESS10.1093/ehjci/jead171Cardiac & Cardiovascular SystemsRadiology, Nuclear Medicine & Medical Imaging2047-2412