Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPMORAES, Oscar A.COLUCCI, Juliana A.SOUZA, Leandro E.SCAPINI, Katia B.MORAES-SILVA, Ivana C.MOSTARDA, CristianoANGELIS, Katia DeCASARINI, Dulce E.IRIGOYEN, Maria Claudia2014-01-282014-01-282013AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v.177, n.2, p.143-147, 20131566-0702https://observatorio.fm.usp.br/handle/OPI/4539It is known that diabetes is associated with autonomic dysfunction; however, data about autonomic function in non-obese diabetic mice (NOD) remain scarce. We evaluated the autonomic profile of NOD mice. Female mice, 24-28 week old, were divided in two groups: NOD (n = 6) and control (n = 6, Swiss mice). NOD mice with glycemia >= 300 mg/dl were used. Heart rate variability (HRV) and arterial pressure variability (APV) in time and frequency domains, symbolic analysis of heart rate (HR) and baroreflex sensitivity were evaluated. HR and arterial pressure (AP) were similar between the groups; however, HRV (total variance of RR interval: NOD = 21.07 +/- 3.75 vs. C = 42.02 +/- 6.54 ms(2)) and the vagal modulation index RMSSD were lower in NOD group (4.01 +/- 032 vs. 8.28 +/- 0.97 ms). Moreover, the absolute and normalized low-frequency (LF) components were also enhanced in NOD (normalized = 61.0 +/- 4.0%) as compared to control mice (normalized = 20.0 +/- 4.0%). Both the absolute and normalized high-frequency (HF) components were lower in NOD (normalized = 39.0 +/- 4.0%) when compared to the control group (normalized = 80.0 +/- 4.0). In the symbolic analysis the 0V pattern, an indication of sympathetic activity, was higher in NOD and 2LV pattern, an indication of parasympathetic activity, was lower in the NOD than in the control group. Both bradycardic and tachycardic responses were decreased in NOD (3.01 +/- 0.72 vs. 4.54 +/- 0.36 bpm/mm Hg and 2.49 +/- 031 vs. C = 3.43 +/- 033 bpm/mm Hg) when compared to the control group. Correlation analysis showed negative correlations between vagal indexes (RMSSD, %HF and 2LV) and glycemic levels. In conclusion, NOD mice develop severe diabetes correlated with autonomic dysfunction.engrestrictedAccessDiabetes mellitusAutonomic nervous systemBaroreflexMiceInbred NODheart-rate-variabilityrenin-angiotensin systemnod micebaroreflex sensitivityarterial-pressurereflex controlratsneuropathymodulationmodelarticleCopyright ELSEVIER SCIENCE BV10.1016/j.autneu.2013.03.011Neurosciences