Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPOUTHRED, TimHAWKSHEAD, Brittany E.WAGER, Tor D.DAS, PrithaMALHI, Gin S.KEMP, Andrew H.2014-01-282014-01-282013NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v.37, n.8, p.1786-1800, 20130149-7634https://observatorio.fm.usp.br/handle/OPI/4642Clinical research has demonstrated differential efficacy of selective serotonin reuptake inhibitors (SSRIs) and norepinephrine reuptake inhibitors (NRIs), which may relate to differential acute effects these medications have on emotional brain processes. Here we present findings from a Multi-Level Kernel Density Analysis meta-analysis that integrates and contrasts activations from disparate fMRI studies in order to examine whether single dose SSRIs and NRIs have different effects on emotion processing tasks in healthy participants. Seven SSRI and four NRI studies were eligible for inclusion. SSRIs decreased amygdala responses, suggesting reduced emotional reactivity to emotional stimuli, whereas NRIs increased frontal and medial activation, suggesting increased emotion regulation. As hypothesised, an interaction of antidepressant and task type was found, such that SSRIs modulated amygdaloid-hippocampal, medial and frontal activity during both the presentation of faces and pictures, whereas NRIs only modulated the activation in medial and frontal regions during the presentation of pictures. Findings are interpreted within a novel model of the differential effects of SSRIs and NRIs on emotion processing.engrestrictedAccessAntidepressantsSSRINRISerotoninNoradrenalinEmotionfMRIMulti-Level Kernel Density Analysis Meta-analysisanterior cingulate cortexcognitive neuropsychological modelantidepressant drug-actionmajor depressive disordersuperior temporal gyrusprefrontal cortexhealthy-volunteersincreased amygdalaaffective neurosciencefacial expressionsarticleCopyright PERGAMON-ELSEVIER SCIENCE LTD10.1016/j.neubiorev.2013.07.010Behavioral SciencesNeurosciences