Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPASSONE, TatianeMALTA, Fernanda M.BAKKOUR, SoniaMONTALVO, LeilaniPAIVA, Arthur M.SMID, JerusaOLIVEIRA, Augusto Cesar Penalva deGONCALVES, Fernanda de ToledoLUIZ, Olinda do CarmoFONSECA, Luiz Augusto M.NORRIS, Philip J.CASSEB, Jorge2018-05-082018-05-082018VIRUS RESEARCH, v.244, Special Issue, p.71-74, 20180168-1702https://observatorio.fm.usp.br/handle/OPI/26589Introduction: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. Methods: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases ""Emilio Ribas"" (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016. The subjects were classified according to their neurological status into two groups: Group 1 (160 asymptomatic individuals) and Group 2 (87 HAM/TSP patients). Samples were tested for spontaneous lymphocyte proliferation (LPA) and HTLV-1 proviral load (PVL) and for IFN-lambda 4, HLA-C and KIR genotypes using qPCR. Results: We found associations between LPA (p = 0.0001) with HAM/TSP and confirmed the IFN-lambda 4 polymorphism rs8099917, allele GG, as a protective factor using a recessive model (OR = 3.22, CI = 1.10-9.47). Polymorphisms in HLA-C and KIR alleles were not associated with risk of developing HAM/TSP. Conclusion: We demonstrated that age, LPA and an IFN-lambda 4 polymorphism were associated with progression to HAM/TSP. Understanding HAM/TSP pathogenesis can provide important markers of prognostic value for clinical management, and contribute to the discovery of new therapeutic interventions in the future.engrestrictedAccessPolymorphismsInterferonsHTLV-1HLA antigensmyelopathy/tropical spastic paraparesisvirus type-ihtlv-1 proviral loadcd8(+) t-cellsreal-time pcrtype-1 htlv-1infectionpathogenesisdiseasetherapyarticleCopyright ELSEVIER SCIENCE BV10.1016/j.virusres.2017.11.010Virology1872-7492