Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPNICODEMO, Antonio C.DUARTE-NETO, Amaro Nunes2021-08-132021-08-132021AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.104, n.6, p.1970-1972, 20210002-9637https://observatorio.fm.usp.br/handle/OPI/41456Based on a previous study and by incorporating new knowledge, the goal of our study was to understand more fully the pathogenesis of hemorrhagic pneumonia of severe human leptospirosis, highlighting the onset of capillary lesions by Leptospira itself and/or its antigenic/toxic products acting on the endothelium and binding to cadherins. Both events lead to loss of endothelial integrity, alter permeability, cause rupture, and open intercellular junctions, contributing to the hemorrhagic phenomena associated with severe leptospirosis.engrestrictedAccessarticleCopyright AMER SOC TROP MED & HYGIENE10.4269/ajtmh.20-1000Public, Environmental & Occupational HealthTropical Medicine1476-1645