Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSOBREIRO, Matildes F. M.MIOTTO, Eliane CorreaTERRONI, LuisaTINONE, GiselaIOSIFESCU, Dan V.LUCIA, Mara C. S. deSCAFF, MilbertoLEITE, Claudia da CostaAMARO JR., EdsonFRAGUAS, Renerio2014-09-302014-09-302014JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, v.36, n.6, p.636-647, 20141380-3395https://observatorio.fm.usp.br/handle/OPI/7550The depression-executive dysfunction syndrome, a late-onset depression of vascular origin with executive dysfunction and psychomotor retardation, has also been described after stroke. We verified whether this syndrome also occurs in nonelderly stroke patients by investigating the association between domains of depressive symptoms with executive functions in 87 first-ever ischemic stroke patients. The retardation domain of the 31-item Hamilton Rating Scale for Depression was associated with decreased performance on verbal fluency (assessed with FAS). The association was maintained for younger patients (aged <60 years) after adjusting for confounders. This result supports the clinical presentation of depression-executive dysfunction syndrome in younger stroke patients. Confirmation of this finding, its neural correlates, and clinical implication deserve further investigation.engrestrictedAccessExecutive functionsDepressive symptomsStrokeNeuropsychological testsVascular depressionlate-life depressionvascular cognitive impairmentwhite-matter hyperintensitieshuman cerebral-cortexpoststroke depressiondysfunction syndromefollow-upneuropsychological deficitsantidepressant-treatmentclinical determinantsarticleCopyright TAYLOR & FRANCIS INC10.1080/13803395.2014.925092Psychology, ClinicalClinical NeurologyPsychology1744-411X