Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPMATSUSHITA, F.Y.KREBS, V.L.J.CARVALHO, W.B. de2020-04-032020-04-032019CURRENT TREATMENT OPTIONS IN PEDIATRICS, v.5, n.4, p.406-416, 20192198-6088https://observatorio.fm.usp.br/handle/OPI/35749Purpose of review: There is no consensus in the treatment of hemodynamic instability in the preterm newborn. Blood pressure is one of the few measurable objective parameters for hemodynamic evaluation in this population. However, little is known about the efficacy of anti-hypotensive treatments in newborns. The objective of this review is to identify and analyze the efficacy of a given anti-hypotensive intervention in improving the hypotensive preterm newborn. Recent findings: With the increase in survival of the preterm newborns, there was an augmentation in the interest for the treatment of hypotension in this population. However, as there are doubts regarding the efficacy in anti-hypotensive treatment, new drugs are being used to reverse the hypotensive state in preterm infants: epinephrine, norepinephrine, vasopressin, and steroids. Summary: We have identified that classically used medications in the treatment of hypotension have little evidence of efficacy in rescuing the preterm infant from the hypotensive state. New therapies are emerging with potential benefits, especially in refractory hypotension such as epinephrine and norepinephrine, but more prospective studies are needed. Literature review should be careful, considering the definition used for hypotension, the time of onset, the intravascular volume status of each patient, and if the drug was used as a first or second line of treatment. © 2019, Springer Nature Switzerland AG.engrestrictedAccessHypotensionInotropePrematureVolume resuscitationdobutaminedopamineepinephrinehypertensive agentnoradrenalinsteroidvasopressinbirth weightblood flowblood pressurebrain hemorrhagedose responsedrug efficacyevaluation studygestational ageheart outputhumanhypotensionmean arterial pressuremortalitynewbornnewborn periodprematuritypriority journalprognosisresuscitationreviewsystematic reviewtissue perfusionarticleCopyright SPRINGER10.1007/s40746-019-00175-2