Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPDINIZ, Breno S.NUNES, Paula V.MACHADO-VIEIRA, RodrigoFORLENZA, Orestes V.2017-11-272017-11-272011CURRENT OPINION IN PSYCHIATRY, v.24, n.6, p.473-477, 20110951-7367https://observatorio.fm.usp.br/handle/OPI/23376Purpose of review This work aims to review the most recent developments in the treatment of mood disorders (major depression and bipolar disorder) in the elderly. Recent findings In the last years, few new pharmacological interventions for mood disorders have been developed. Recent studies seek to provide alternative treatment strategies to achieve higher remission rates, including the association of antidepressants, mood stabilizers and psychotherapy and the treatment of specific clusters of symptoms, such as the adjunctive treatment of cognitive impairment with cholinesterase inhibitors. Also, recent studies have been assessing the potential of pharmacogenetic information in the prediction of treatment outcomes. Summary These factors altogether are expected to help the development of personalized treatment strategies that may improve outcomes with fewer adverse effects.engrestrictedAccessantidepressantsbipolar disordermajor depressionmood disordersmood stabilizerstreatmentlate-life depressionrandomized controlled-trialanxiety treatments canmatdouble-blindbipolar disorderolder-adultsmaintenance treatmentcognitive impairmentresidual symptomscanadian networkarticleCopyright LIPPINCOTT WILLIAMS & WILKINS10.1097/YCO.0b013e32834bb9bdPsychiatry