Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPAMORIM, Jaqueline Cristina deTORRICELLI, Aline KuhlFRITTOLI, Renan BazucoLAPA, Aline TamiresDERTKIGIL, Sergio San JuanREIS, FabianoCOSTALLAT, Lilian T. L.FRANCA JUNIOR, Marcondes CavalcanteAPPENZELLER, Simone2019-08-202019-08-202018BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, v.32, n.5, p.623-639, 20181521-6942https://observatorio.fm.usp.br/handle/OPI/33261Systemic lupus erythematosus (SLE), presenting with new onset or worsening neuropsychiatric (NP) symptoms, is a challenge in clinical practice. Mimickers such as infections, drug-induced side effects, metabolic abnormalities, malignancies, and alcohol-related disorders have to be excluded, before attributing the manifestations to disease activity. Proper diagnosis is essential to guide adequate management and reduce morbidity and mortality. In this review article, we will highlight clinical, laboratorial, and neuroradiological features that are helpful to assist in the differential diagnosis. (C) 2019 Published by Elsevier Ltd.engrestrictedAccessMimickersNeuropsychiatric manifestationsSystemic lupus erythematosuscentral-nervous-systemb-cell lymphomamycophenolate-mofetillimbic encephalitisneuromyelitis-opticatransverse myelitisinduced meningitishistogram analysisdiabetes-mellitusdevics-syndromearticleCopyright ELSEVIER SCI LTD10.1016/j.berh.2019.01.020Rheumatology1521-1770