Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPRODRIGUEZ, Roberta DiehlSUEMOTO, Claudia KimieMOLINA, MarianaNASCIMENTO, Camila FernandesLEITE, Renata Elaine ParaizoFERRETTI-REBUSTINI, Renata Eloah de LucenaFARFEL, Jose MarceloHEINSEN, HelmutNITRINI, RicardoUEDA, KenjiPASQUALUCCI, Carlos AugustoJACOB-FILHO, WilsonYAFFE, KristineGRINBERG, Lea Tenenholz2016-10-172016-10-172016JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, v.75, n.7, p.628-635, 20160022-3069https://observatorio.fm.usp.br/handle/OPI/16083Argyrophilic grain disease (AGD) is a frequent late-onset, 4 repeat tauopathy reported in Caucasians with high educational attainment. Little is known about AGD in non-Caucasians or in those with low educational attainment. We describe AGD demographics, clinical, and neuropathological features in a multiethnic cohort of 983 subjects >50 years of age from Sao Paulo, Brazil. Clinical data were collected through semistructured interviews with an informant and included in the Informant Questionnaire on Cognitive Decline in the Elderly, the Clinical Dementia Rating, and the Neuropsychiatric Inventory. Neuropathologic assessment relied on internationally accepted criteria. AGD was frequent (15.2%) and was the only neuropathological diagnosis in 8.9% of all cases (mean, 78.9 +/- 9.4 years); it rarely occurred as an isolated neuropathological finding. AGD was associated with older age, lower socioeconomic status (SES), and appetite disorders. This is the first study of demographic, clinical, and neuropathological aspects of AGD in different ethnicities and subjects from all socioeconomic strata. The results suggest that prospective studies of AGD patients include levels of hormones related to appetite control as possible antemortem markers. Moreover, understanding the mechanisms behind higher susceptibility to AGD of low SES subjects may disclose novel environmental risk factors for AGD and other neurodegenerative diseases.engrestrictedAccessDementiaNeurodegenerationNeuropathologyPostmortemTauopathyprogressive supranuclear palsymild cognitive impairmenthyperphosphorylated tau-proteinadult-onset dementiaalzheimers-diseaseparkinsons-diseaseapolipoprotein-e4-repeat tauopathiessocioeconomic-statusballooned neuronsarticleCopyright LIPPINCOTT WILLIAMS & WILKINS10.1093/jnen/nlw034Clinical NeurologyNeurosciencesPathology