Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPRAHMI, Rosa MariaOLIVEIRA, Priscila deSELISTRE, LucianoREZENDE, Paulo CuryPEZZELLA, Gabriela NeuvaldSANTOS, Pamela Antoniazzi dosVERGANI, Daiane de Oliveira PereiraMADI, Sonia Regina CabralMADI, Jose Mauro2021-08-132021-08-132021PLOS ONE, v.16, n.6, article ID e0253047, 10p, 20211932-6203https://observatorio.fm.usp.br/handle/OPI/41749Objective The objective of the present study was to compare 24-hour glycemic levels between obese pregnant women with normal glucose tolerance and non-obese pregnant women. Methods In the present observational, longitudinal study, continuous glucose monitoring was performed in obese pregnant women with normal oral glucose tolerance test with 75 g of glucose between the 24(th) and the 28(th) gestational weeks. The control group (CG) consisted of pregnant women with normal weight who were selected by matching the maternal age and parity with the same characteristics of the obese group (OG). Glucose measurements were obtained during 72 hours. Results Both the groups were balanced in terms of baseline characteristics (age: 33.5 [28.7-36.0] vs. 32.0 [26.0-34.5] years, p = 0.5 and length of pregnancy: 25.0 [24.0-25.0] vs. 25.5 [24.0-28.0] weeks, p = 0.6 in the CG and in the OG, respectively). Pre-breakfast glycemic levels were 77.77 10.55 mg/dL in the CG and 82.02 +/- 11.06 mg/dL in the OG (p<0.01). Glycemic levels at 2 hours after breakfast were 87.31 <plus/minus> 13.10 mg/dL in the CG and 93.48 +/- 18.74 mg/dL in the OG (p<0.001). Daytime blood glucose levels were 87.6 <plus/minus> 15.4 vs. 93.1 +/- 18.3 mg/dL (p<0.001) and nighttime blood glucose levels were 79.3 <plus/minus> 15.8 vs. 84.7 +/- 16.3 mg/dL (p<0.001) in the CG and in the OG, respectively. The 24-hour, daytime, and nighttime values of the area under the curve were higher in the OG when compared with the CG (85.1 <plus/minus> 0.16 vs. 87.9 +/- 0.12, 65.6 +/- 0.14 vs. 67.5 +/- 0.10, 19.5 +/- 0.07 vs. 20.4 +/- 0.05, respectively; p<0.001). Conclusion The results of the present study showed that obesity in pregnancy was associated with higher glycemic levels even in the presence of normal findings on glucose tolerance test.engopenAccessgestational diabetes-mellitusmaternal obesityoutcomesarticleCopyright PUBLIC LIBRARY SCIENCE10.1371/journal.pone.0253047Multidisciplinary Sciences