Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPBERALDO, Daniel OliveiraMELO, Joanderson FernandesBONFIM, Alexandre VidalTEIXEIRA, Andrei AlkmimTEIXEIRA, Ricardo AlkmimDUARTE, Andre Loyola2014-04-252014-04-252013WORLD JOURNAL OF GASTROENTEROLOGY, v.19, n.46, p.8789-8792, 20131007-9327https://observatorio.fm.usp.br/handle/OPI/5259Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used, especially for the treatment of respiratory and cutaneous infections. In general, it is a well-tolerated oral antibiotic. However, amoxicillin/clavulanate can cause adverse effects, mainly cutaneous, gastrointestinal, hepatic and hematologic, in some cases. Presented here is a case report of a 63-year-old male patient who developed cholestatic hepatitis after recent use of amoxicillin/clavulanate. After 6 wk of prolonged use of the drug, he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia (total bilirubin > 300 mg/L). Diagnostic investigation was conducted by ultrasonography of the upper abdomen, serum tests for infection history, laboratory screening of autoimmune diseases, nuclear magnetic resonance (NMR) of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by ultrasound. The duration of disease was approximately 4 mo, with complete resolution of symptoms and laboratory changes at the end of that time period. Specific treatment was not instituted, only a combination of anti-emetic (metoclopramide) and cholestyramine for pruritus.engopenAccessHepatologyHepatitisAmoxicillin/ClavulanateDrug reactionsHyperbilirubinemiaamoxicillin-clavulanic aciddrug-induced hepatitishepatotoxicityassociationarticleCopyright BAISHIDENG PUBL GRP CO LTD10.3748/wjg.v19.i46.8789Gastroenterology & Hepatology2219-2840