Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPFONOFF, Erich TalamoniCAMPOS, Wuilker KnonerMANDEL, MauricioALHO, Eduardo Joaquim LopesTEIXEIRA, Manoel Jacobsen2013-07-302013-07-302012MOVEMENT DISORDERS, v.27, n.12, p.1559-1563, 20120885-3185https://observatorio.fm.usp.br/handle/OPI/495Background: Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities. Methods: Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the BurkeFahnMarsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery. Results: All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025). Conclusions: These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy. (c) 2012 Movement Disorder SocietyengrestrictedAccessdystoniathalamotomypallidotomysubthalamic nucleusdeep-brain-stimulationquality-of-lifeglobus-pallidussegmental dystoniaunilateral pallidotomydisordersarticleCopyright WILEY-BLACKWELL10.1002/mds.25127Clinical Neurology