Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPROSENBLATT, AlbertoFAINTUCH, JoelPAJECKI, DenisSANTO, Marco AurelioFAINTUCH, SalomaoCECCONELLO, Ivan2017-10-242017-10-242017BARIATRIC SURGICAL PRACTICE AND PATIENT CARE, v.12, n.3, p.94-99, 20172168-023Xhttps://observatorio.fm.usp.br/handle/OPI/21906Background: Obesity poses challenges to male reproduction, but the effect of bariatric surgery on semen parameters and fertility is debated. This study evaluates Roux-en-Y gastric bypass (RYGB) influence on these variables. Methods: Seventy-nine sexually active men attempting to conceive with a partner were stratified into four groups: Group 1 (n = 23)-bariatric follow-up >= 5 years; Group 2 (n = 23)-mean bariatric follow-up 2 years; Group 3-obese controls (n = 18); Group 4-lean controls (n = 15). Groups 2, 3, and 4 were matched for age; Groups 1, 2, and 3 were matched for body mass index (BMI). Sexual quality of life questionnaire for males (SQOL-M), fasting blood glucose, C-reactive protein, vitamin D, zinc, total testosterone (TT), and free testosterone (FT), estradiol (E2), sex hormone-binding globulin (SHBG), and semen parameters were investigated. Results: SQOL-M scores increased; vitamin D was low in most of Group 2 and Group 3 participants, negatively correlating with BMI (p < 0.01). TT, FT, and SHBG improved postoperatively; however, E2 remained elevated. Semen aberrations occurred in 57.1% of Group 2 patients and BMI correlated with oligoasthenoteratospermia. Scant bariatric men fathered a child (13.0% preoperatively, 4.3% postoperatively, not significant). Conclusion: Semen abnormalities and subfertility were observed after RYGB, despite improved androgenic profile and SQOL-M. Possible negative impacts of hyperestrogenism and hypovitaminosis D on semen parameters warrant further studies.engrestrictedAccessbariatric surgerysemen analysismale fertilitysex hormonesandrogensvitaminstrace elementsmale obesityy gastric bypassbody-mass indexvitamin-dhuman osteoblastssperm parameterslong-termdeficienciesmetaanalysisassociationinfertilityarticleCopyright MARY ANN LIEBERT, INC10.1089/bari.2017.0016Nursing2168-0248