Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPBRANDAO, Michele MadeiraTONELLO, CristianoPARIZOTTO, IsabellaMACHADO, Luciano BrandaoALONSO, Nivaldo2024-04-052024-04-052024CHILDS NERVOUS SYSTEM, v.40, n.1, p.145-152, 20240256-7040https://observatorio.fm.usp.br/handle/OPI/58727PurposeCraniosynostosis can lead to symptoms resulting from cranial compliance (CC) changes and intracranial hypertension (ICH), which may cause cognitive and visual impairment. Non-invasive methods have emerged, including a new device that captures and processes the intracranial pressure waveform (ICPw) by the skull's oscillation. The present study evaluates ICPw obtained non-invasively (NIICPw) in patients with craniosynostosis.MethodsThis prospective, cross-sectional, and descriptive study was conducted at a single center. Patients diagnosed with craniosynostosis and who provided informed consent were included. A US Food and Drug Administration-approved mechanical extensometer device (Brain4Care Corp.) was used to obtain a NIICPw. An ophthalmologist did a point-of-care retinography to check the optic nerve papilla. The P2/P1 ratio and the morphology of the NIICPw were analyzed, as well as the retinography.ResultsThirty-five patients were evaluated, and 42 registers were obtained because seven were assessed before and after the surgery. The two patients who presented papilledema had low CC (NIICPw shape Class 3 or 4). There was a significant association between NIICPw and papilledema.ConclusionThe ratio P2/P1 and the NIICPw morphology provided by a non-invasive monitor are related to CC changes before papilledema occurs. This is especially useful in patients with craniosynostosis because invasive ICP monitoring is not always feasible. Further studies are warranted to establish the clinical utility of NIICPw in patients with craniosynostosis.engrestrictedAccessIntracranial hypertensionCraniosynostosisIntracranial pressurePapilledemahypertensionrecordingschildrenvolumearticleCopyright SPRINGER10.1007/s00381-023-06092-yClinical NeurologyPediatricsSurgery1433-0350