Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSUI, YananTIAN, YeKO, Wai Kin DanielWANG, ZhiyanJIA, FuminHORN, AndreasRIDDER, Dirk DeCHOI, Ki SuengBARI, Ausaf A.WANG, ShouyanHAMANI, ClementBAKER, Kenneth B.MACHADO, Andre G.AZIZ, Tipu Z.FONOFF, Erich TalamoniKUHN, Andrea A.BERGMAN, HagaiSANGER, TerenceLIU, HeshengHABER, Suzanne N.LI, Luming2021-04-152021-04-152021FRONTIERS IN NEUROLOGY, v.11, article ID 597451, 21p, 20211664-2295https://observatorio.fm.usp.br/handle/OPI/39908Deep brain stimulation (DBS) is one of the most important clinical therapies for neurological disorders. DBS also has great potential to become a great tool for clinical neuroscience research. Recently, the National Engineering Laboratory for Neuromodulation at Tsinghua University held an international Deep Brain Stimulation Initiative workshop to discuss the cutting-edge technological achievements and clinical applications of DBS. We specifically addressed new clinical approaches and challenges in DBS for movement disorders (Parkinson's disease and dystonia), clinical application toward neurorehabilitation for stroke, and the progress and challenges toward DBS for neuropsychiatric disorders. This review highlighted key developments in (1) neuroimaging, with advancements in 3-Tesla magnetic resonance imaging DBS compatibility for exploration of brain network mechanisms; (2) novel DBS recording capabilities for uncovering disease pathophysiology; and (3) overcoming global healthcare burdens with online-based DBS programming technology for connecting patient communities. The successful event marks a milestone for global collaborative opportunities in clinical development of neuromodulation to treat major neurological disorders.engopenAccessneuromoxdulationdepressiondeep brain stimulationMRI compatibilitygait disabilityarticleCopyright FRONTIERS MEDIA SA10.3389/fneur.2020.597451Clinical NeurologyNeurosciences