Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPVEIGA, Eduardo Carvalho de ArrudaLEVY, Rozeli FerreiraBOCALINI, Danilo SalesJR, Jose Maria SoaresBARACAT, Edmund ChadaCAVALLI, Ricardo CarvalhoSANTOS, Leonardo dos2023-12-152023-12-152023IJC HEART & VASCULATURE, v.46, article ID 101214, 11p, 2023https://observatorio.fm.usp.br/handle/OPI/57478Background: Despite the success of interventional coronary reperfusion strategies, morbidity and mortality from acute myocardial infarction are still substantial. Physical exercise is a well-recognized effective nonpharmacological therapy for cardiovascular diseases. Therefore, the objective of this systematic review was to analyze studies in animal models of ischemia-reperfusion in association with physical exercise protocols.Search strategy: Articles published on the topic over a 13-year period (2010-2022) were searched in two databases (PubMed and Google Scholar) using the keywords exercise training, ischemia/reperfusion or ischemia reperfusion injury. Meta-analysis and quality assessment of the studies were performed using the Review Manager 5.3 program.Results: From the 238 articles retrieved from PubMed and 200 from Google Scholar, after screening and eligibility assessment, 26 articles were included in the systematic review and meta-analysis. For meta-analysis comparing the group of previously exercised animals with the non-exercised animals and then submitted to ischemia-reperfusion, the infarct size was significantly decreased by exercise (p < 0.00001). In addition, the group exercised had increased heart-to-body weight ratio (p < 0.00001) and improved ejection fraction as measured by echocardiography (p < 0.0004) in comparison to non-exercised animals.Conclusion: We concluded that the animal models of ischemia-reperfusion indicates that exercise reduce infarct size and preserve ejection fraction, associated with beneficial myocardial remodeling.engopenAccessExerciseIschemiareperfusionTrainingreperfusion injuryCardio protectionMyocardial infarctioninduced cardioprotectionheartimpactarticleCopyright ELSEVIER IRELAND LTD10.1016/j.ijcha.2023.101214Cardiac & Cardiovascular Systems2352-9067