Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSOARES, Pedro San MartinBARROS, Aluisio Jardim Dornellas deSANTOS, Ina dosMATIJASEVICH, AliciaWEHRMEISTER, Fernando CesarMENEZES, Ana Maria BaptistaGONCALVES, HelenHARTWIG, Fernando Pires2024-04-052024-04-052024JOURNAL OF AFFECTIVE DISORDERS, v.351, p.151-157, 20240165-0327https://observatorio.fm.usp.br/handle/OPI/58977Maternal mental health during different stages of life can have a significant impact on a child's cognitive development. This study aimed to investigate the association between maternal CMD at two distinct stages of the offspring's life (at 3 months and 11 years) and their IQ scores at 6 and 18 years across two birth cohorts. The study utilized data from two Brazilian birth cohorts: the 1993 cohort (full sample: N = 3719, subsample: N = 436), and the 2004 Pelotas Birth Cohort (N = 3440). IQ assessments were conducted at ages 18 and 6, employing the Wechsler Adult Intelligence Scale, third version (WAIS-III), and Wechsler Intelligence Scale for Children, third version (WISC-III), respectively. The presence of maternal CMD at 3 months and 11 years of age was evaluated using the Brazilian version of the Self-Reporting Questionnaire (SRQ-20). After adjustment, participants whose mothers experienced CMD at 3 months had average IQ scores 1.74 (95 % CI: -2.83 to -0.67) and 2.79 (95 % CI: -5.54 to -0.04) points lower at ages 6 (2004 cohort) and 18 (1993 cohort subsample), respectively. Furthermore, in the 1993 cohort (both full and subsample), maternal CMD at 11 years was associated with lower IQ scores at age 18. Understanding the mechanisms underlying this association, emphasized by these findings, is crucial for promoting children's cognitive development, educational achievement, and overall well-being.engrestrictedAccessMaternal mental healthCognitionIntelligenceLongitudinal studypsychiatric screening questionnairedepressive symptomsprofile updatefollow-upperformancechildrenvalidityanxietystressarticleCopyright ELSEVIER10.1016/j.jad.2024.01.164Clinical NeurologyPsychiatry1573-2517