Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSEDASSARI, Bruno TavaresLASCANE, Nelise Alexandre da SilvaFREITAS, Andre Luis Santana deMAUTONI, Mario ClaudioSOTTO, Mirian NacagamiGALLOTTINI, Marina Helena CurySOUSA, Suzana Cantanhede Orsini Machado dePINTO JR., Decio dos Santos2017-04-072017-04-072016HEAD & NECK PATHOLOGY, v.10, n.4, p.547-551, 20161936-055Xhttps://observatorio.fm.usp.br/handle/OPI/18816Melanoma is a highly aggressive neoplasm in which the neoplastic cells display melanocytic differentiation. Less than 1 % of all melanomas arise in the mucosal surfaces of the oral cavity, with purely in situ lesions being exceedingly rare tumors, but with a favorable prognosis compared with invasive lesions. We describe the clinical, histopathological and immunohistochemical findings in an uncommon case of in situ mucosal melanoma of the oral cavity with intense tumor-associated pigment deposition and inflammation complicating the morphological assessment of infiltrative areas.engrestrictedAccessImmunohistochemistryMucosal melanomaOral mucosaSkin tumorsoral mucosal melanomaarticleCopyright SPRINGER10.1007/s12105-016-0728-3Pathology1936-0568