Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSANABANI, Sabri SaeedNUKUI, YoukoPEREIRA, JulianaCOSTA, Antonio Charlys daOLIVEIRA, Ana Carolina Soares dePESSOA, RodrigoLEAL, Fabio EudesSEGURADO, Aluisio C.KALLAS, Esper GeorgesSABINO, Ester Cerdeira2013-07-302013-07-302012BMC INFECTIOUS DISEASES, v.12, article ID 374, 6p, 20121471-2334https://observatorio.fm.usp.br/handle/OPI/729Background: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results: All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions: Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population.engopenAccessHTLV-1ILB 28 polymorphismsHAM/TSPProviral loadt-cell leukemiavirus type-ichronic hepatitis-cgenome-wide associationtumor-necrosis-factorgenetic-variationinterleukin-10 promoterspastic paraparesishiv-infectionpolymorphismarticleCopyright BIOMED CENTRAL LTD10.1186/1471-2334-12-374Infectious Diseases