Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPVANDERHASSELT, Marie-AnneSANCHEZ-LOPEZ, AlvaroPULOPULOS, MatiasRAZZA, Lais B.SMET, Stefanie DeBRUNONI, Andre RussowskyBAEKEN, ChrisRAEDT, Rudi DeALLAERT, Jens2023-06-212023-06-212023INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY, v.23, n.4, article ID 100384, 9p, 20231697-2600https://observatorio.fm.usp.br/handle/OPI/53813The prefrontal cortex plays a crucial role in cognitive processes, both during anticipatory and reactive modes of cognitive control. Transcranial Direct Current Stimulation (tDCS) can modulate these cognitive resources. How-ever, there is a lack of research exploring the impact of tDCS on emotional material processing in the prefrontal cortex, particularly in regard to proactive and reactive modes of cognitive control. In this study, 35 healthy volun-teers underwent both real and sham tDCS applied to the right prefrontal cortex in a counterbalanced order, and then completed the Cued Emotion Control Task (CECT). Pupil dilation, a measure of cognitive resource allocation, and behavioral outcomes, such as reaction time and accuracy, were collected. The results indicate that, as com-pared to sham stimulation, active right-sided tDCS reduced performance and resource allocation in both proactive and reactive modes of cognitive control. These findings highlight the importance of further research on the effects of tDCS applied to the right prefrontal cortex on cognitive engagement, particularly for clinical trials utilizing the present electrode montage in combination with cognitive interventions.engrestrictedAccessNeuromodulationRight prefrontal cortexPupil dilationProactive and reactive cognitive controlAnticipationcognitive controltdcsinformationvalidationmechanismsfacesarticleCopyright ELSEVIER SCIENCE INC10.1016/j.ijchp.2023.100384Psychology, Clinical1576-7329