Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPMARCONDES-BRAGA, Fabiana G.MURAD, Ciro M.BELFORT, Deborah S. P.DANTAS, Rafael C. T.LIRA, Maria Tereza S. S.ARAGAO, Carlos A. S.SICILIANO, Rinaldo F.MANGINI, SandrigoSEGURO, Luis Fernando B. C.CAMPOS, Iascara W.AVILA, Monica S.BELLO, Mariana V. O.SANTOS, Fernanda B. A. dosV, Tania M. StrabelliGAIOTTO, Fabio A.BACAL, Fernando2022-04-192022-04-192022TRANSPLANTATION, v.106, n.3, p.641-647, 20220041-1337https://observatorio.fm.usp.br/handle/OPI/46227Background. Heart transplant (HT) recipients may be at higher risk of acquiring SARS-CoV-2 infection and developing critical illness. The aim of this study is to describe characteristics and outcomes of HT recipients infected by SARS-COV-2, from a high-volume transplant center. Methods. We have described data of all adult HT recipients with confirmed coronavirus disease 2019 by RT-PCR in nasopharyngeal samples from April 5, 2020, to January 5, 2021. Outcomes and follow-up were recorded until February 5, 2021. Results. Forty patients were included. Twenty-four patients (60%) were men; the median age was 53 (40-60) y old; median HT time was 34 mo; and median follow-up time 162 d. The majority needed hospitalization (83%). Immunosuppressive therapy was reduced/withdrawn in the majority of patients, except from steroids, which were maintained. Seventeen patients (42.5%) were classified as having severe disease according to the ordinal scale developed by the World Health Organization Committee. They tended to have lower absolute lymphocyte count (P < 0.001) during follow-up when compared with patients with mild disease. Thirty-day mortality was 12.5%. However, a longer follow-up revealed increased later mortality (27.5%), with median time to death around 35 d. Bacterial nosocomial infections were a leading cause of death. Cardiac allograft rejection (10%) and ventricular dysfunction (12.5%) were also not negligible. Conclusions. Major findings of this study corroborate other cohorts' results, but it also reports significant rate of later events, suggesting that a strict midterm surveillance is advisable to HT recipients with coronavirus disease 2019.engrestrictedAccesssolid-organ transplantcovid-19articleCopyright LIPPINCOTT WILLIAMS & WILKINS10.1097/TP.0000000000003770ImmunologySurgeryTransplantation1534-6080