PAULA SCHIMIDT BRUM
Projetos de Pesquisa
Unidades Organizacionais
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- The acute effects of strength, endurance and concurrent exercises on the Akt/mTOR/p70S6K1 and AMPK signaling pathway responses in rat skeletal muscle(2013) SOUZA, E.O.de; TRICOLI, V.; BUENO JUNIOR, C.; PEREIRA, M.G.; BRUM, P.C.; OLIVEIRA, E.M.; ROSCHEL, H.; AOKI, M.S.; URGINOWITSCH, C.The activation of competing intracellular pathways has been proposed to explain the reduced training adaptations after concurrent strength and endurance exercises (CE). The present study investigated the acute effects of CE, strength exercises (SE), and endurance exercises (EE) on phosphorylated/total ratios of selected AMPK and Akt/mTOR/p70S6K1 pathway proteins in rats. Six animals per exercise group were killed immediately (0 h) and 2 h after each exercise mode. In addition, 6 animals in a non-exercised condition (NE) were killed on the same day and under the same conditions. The levels of AMPK, phospho-Thr172AMPK (p-AMPK), Akt, phospho-Ser473Akt (p-Akt), p70S6K1, phospho-Thr389-p70S6K1 (p-p70S6K1), mTOR, phospho-Ser2448mTOR (p-mTOR), and phospho-Thr1462-TSC2 (p-TSC2) expression were evaluated by immunoblotting in total plantaris muscle extracts. The only significant difference detected was an increase (i.e., 87%) in Akt phosphorylated/total ratio in the CE group 2 h after exercise compared to the NE group (P = 0.002). There were no changes in AMPK, TSC2, mTOR, or p70S6K1 ratios when the exercise modes were compared to the NE condition (P ≥ 0.05). In conclusion, our data suggest that low-intensity and low-volume CE might not blunt the training-induced adaptations, since it did not activate competing intracellular pathways in an acute bout of strength and endurance exercises in rat skeletal muscle.
- Multidisciplinary rehabilitation program: effects of a multimodal intervention for patients with Alzheimer's disease and cognitive impairment without dementia(2015) SANTOS, Glenda Dias; NUNES, Paula Villela; STELLA, Florindo; BRUM, Paula Schimidt; YASSUDA, Monica Sanches; UENO, Linda Massako; GATTAZ, Wagner Farid; FORLENZA, Orestes VicenteBackground: Non-pharmalogical interventions represent an important complement to standard pharmalogical treatment in dementia. Objective: This study aims to evaluate the effects of a multidisciplinary rehabilitation program on cognitive ability, quality of life and depression symptoms in patients with Alzheimer's disease (AD) and cognitive impairment without dementia (CIND). Methods: Ninety-seven older adults were recruited to the present study. Of these, 70 patients had mild AD and were allocated into experimental (n = 54) or control (n = 16) groups. Two additional active comparison groups were constituted with patients with moderate AD (n = 13) or with CIND (n = 14) who also received the intervention. The multidisciplinary rehabilitation program lasted for 12 weeks and was composed by sessions of memory training, recreational activities, verbal expression and writing, physical therapy and physical training, delivered in two weekly 6-hour sessions. Results: As compared to controls, mild AD patients who received the intervention had improvements in cognition (p = 0.021) and quality of life (p = 0.003), along with a reduction in depressive symptoms (p < 0.001). As compared to baseline, CIND patients displayed at the end of the intervention improvements in cognition (p = 0.005) and depressive symptoms (p = 0.011). No such benefits were found among patients with moderate AD. Discussion: This multidisciplinary rehabilitation program was beneficial for patients with mild AD and CIND. However, patients with moderate dementia did not benefit from the intervention.
- Subjective memory and strategy use in mild cognitive impairment and healthy aging(2013) BRUM, Paula Schimidt; YASSUDA, Mônica Sanches; FORLENZA, Orestes VicenteLimited information is available about subjective memory and strategy use in seniors with mild cognitive impairment (MCI). We investigated whether differences exist in the perception of changes in memory, perceived frequency of forgetting, overall memory evaluation, and strategy use between seniors with MCI and unimpaired older adults. The study included 56 participants, aged 60 years and older, including 28 normal controls (NC) and 28 MCI patients. The participants completed the Short Cognitive Performance Test, the Story and Grocery list recall tasks, the 15-item Geriatric Depression Scale, the Memory Complaint Questionnaire for the perception of changes in episodic memory, the McNair Frequency of Forgetting Questionnaire, and a single question that evaluated overall memory. The Bousfield semantic clustering measure was calculated to assess semantic clustering for list recall. The number of underlined words during story encoding was calculated to assess strategy use. Participants with MCI had significantly worse scores on Story and Grocery list recall, semantic clustering, and overall memory evaluation. No differences were found in the number of underlined words. List recall was significantly correlated with semantic clustering in both groups (NC: r = .58, p = .001; MCI: r = .57, p = .002). Participants with MCI appeared to be less efficacious when using memory strategies, which may be associated with poor memory performance.
- Categorization Working Memory Span Task: Validation study of two Brazilian alternate versions(2018) BRUM, Paula Schimidt; BORELLA, Erika; CARRETTI, Barbara; GUIDOTTI, Elena; YASSUDA, Monica SanchesBackgroundThe Categorization Working Memory Span Task (CWMS task) is a complex working memory (WM) span test that has been used previously to assess age and individual differences in WM as well as the relationship between WM and complex aspects of cognition such as listening comprehension. Two alternate versions of the task have been developed to be used as outcome variables in WM training protocol, which mirrors the task involved in the CWMS task. Objectives(1) To translate and adapt the CWMS task for Brazilian Portuguese; (2) to test the equivalence of its 2 alternate versions; (3) to examine temporal stability; (4) to examine the influence of age and schooling on CWMS task; (5) to establish its relationship with other tests of WM. MethodsEighty-one older adults completed version A, and 86 completed version B of the CWMS task. After 6months, a subsample (n=85) completed the same version of the task. ResultsVersions A and B of the task generated comparable scores. Both versions had adequate temporal stability, which was higher for the CWMS total recall, which is the classical variable in this task to represent WM performance, when compared to the other variables generated by the test. The CWMS task variables were moderately correlated with schooling and other cognitive tests (Mini Mental State Examination, Letter-Number Sequencing, Spatial Span Backward, Digit Span Forward). ConclusionsThe 2 versions of the CWMS task were equivalent and stable temporally. The task was influenced by schooling and global cognition.
bookPart A Estimulação Cognitiva no Comprometimento Cognitivo Leve e Doença de Alzheimer no contexto Multidisciplinar(2012) BRUM, Paula Schimidt; YASSUDA, Mônica Sanches- Effects of a multidisciplinar cognitive rehabilitation program for patients with mild Alzheimer's disease(2011) VIOLA, Luciane F.; NUNES, Paula V.; YASSUDA, Monica S.; APRAHAMIAN, Ivan; SANTOS, Franklin S.; SANTOS, Glenda D.; BRUM, Paula S.; BORGES, Sheila M.; OLIVEIRA, Alexandra M.; CHAVES, Gisele F. S.; CIASCA, Eliane C.; FERREIRA, Rita C. R.; PAULA, Vanessa J. R. de; TAKEDA, Oswaldo H.; MIRANDEZ, Roberta M.; WATARI, Ricky; FALCAO, Deusivania V. S.; CACHIONI, Meire; FORLENZA, Orestes V.OBJECTIVE: To evaluate the effects of a multidisciplinary rehabilitation program on cognition, quality of life, and neuropsychiatric symptoms in patients with mild Alzheimer's disease. METHOD: The present study was a single-blind, controlled study that was conducted at a university-based day-hospital memory facility. The study included 25 Alzheimer's patients and their caregivers and involved a 12-week stimulation and psychoeducational program. The comparison group consisted of 16 Alzheimer's patients in waiting lists for future intervention. INTERVENTION: Group sessions were provided by a multiprofessional team and included memory training, computer-assisted cognitive stimulation, expressive activities (painting, verbal expression, writing), physiotherapy, and physical training. Treatment was administered twice a week during 6.5-h gatherings. MEASUREMENTS: The assessment battery comprised the following tests: Mini-Mental State Examination, Short Cognitive Test, Quality of Life in Alzheimer's disease, Neuropsychiatric Inventory, and Geriatric Depression Scale. Test scores were evaluated at baseline and the end of the study by raters who were blinded to the group assignments. RESULTS: Measurements of global cognitive function and performance on attention tasks indicated that patients in the experimental group remained stable, whereas controls displayed mild but significant worsening. The intervention was associated with reduced depression symptoms for patients and caregivers and decreased neuropsychiatric symptoms in Alzheimer's subjects. The treatment was also beneficial for the patients' quality of life. CONCLUSION: This multimodal rehabilitation program was associated with cognitive stability and significant improvements in the quality of life for Alzheimer's patients. We also observed a significant decrease in depressive symptoms and caregiver burden. These results support the notion that structured nonpharmacological interventions can yield adjunct and clinically relevant benefits in dementia treatment.
- Art therapy as an adjuvant treatment for depression in elderly women: a randomized controlled trial(2018) CIASCA, Eliana C.; FERREIRA, Rita C.; SANTANA, Carmen L. A.; FORLENZA, Orestes V.; SANTOS, Glenda D. dos; BRUM, Paula S.; NUNES, Paula V.Objective: There are few quantitative studies on art therapy for the treatment of depression. The objective of this study was to evaluate if art therapy is beneficial as an adjuvant treatment for depression in the elderly. Methods: A randomized, controlled, single-blind study was carried out in a sample of elderly women with major depressive disorder (MDD) stable on pharmacotherapy. The experimental group (EG) was assigned to 20 weekly art therapy sessions (90 min/session). The control group (CG) was not subjected to any adjuvant intervention. Patients were evaluated at baseline and after 20 weeks, using the Geriatric Depression Scale (GDS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and cognitive measures. Results: Logistic regression analysis adjusted for age revealed that women in EG (n=31) had significant improvement in GDS (p = 0.007), BDI (p = 0.025), and BAI (p = 0.032) scores as compared with controls (n=25). No difference was found in the cognitive measures. Conclusion: Art therapy as an adjunctive treatment for MDD in the elderly can improve depressive and anxiety symptoms.