LUCAS DE MACEDO DOS SANTOS

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina

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  • article
    Transcranial direct current stimulation is safe and effective in autoimmune myopathies: a randomised, double-blind, sham-controlled trial
    (2023) SOUSA, L. F. A. de; MISSE, R. G.; SANTOS, L. M. dos; TANAKA, C.; GREVE, J. M. A.; BAPTISTA, A. F.; SHINJO, S. K.
    Objective We aimed to assess the safety and efficacy of transcranial direct current stimulation (tDCS) in patients with systemic autoimmune myopathies (SAMs).Methods This prospective, randomised, sham-controlled, double-blind, study included 20 patients with SAMs allocated to receive sham or active tDCS (2mA, 20 minutes, 3 days). Electrodes were positioned with the anode over the C1 or C2, whereas the cathode was placed over the Fp2 or Fp1, respectively. The groups were evaluated in four periods with specific questionnaires and functional tests: pre-stimulation and after 30 minutes, three weeks, and eight weeks post-tDCS.Results Two patients from the sham group withdrew after the three sessions. The demographic data, type of myositis, disease duration, and disease status were comparable between the active and sham tDCS groups. After interventions, in the active tDCS group, the physical aspects of SF-36 in week eight, mean and better timed up-and-go test at each evaluation, peak torque of stimulated inferior limb extension improved significantly (p<0.05). The emotional aspect of SF-36 decreased only in the active tDCS group (p<0.001). The patients' adherence to the protocol was 100% and no serious adverse event was reported, including disease relapses.Conclusion This study evidences the safety of tDCS, as well as its potential efficacy in improving muscle strength and function in SAMs patients. More studies with a larger sample and longer tDCS sessions are necessary to corroborate the results of the present study.
  • conferenceObject
    TRANSCRANIAL ELECTRICAL STIMULATION IS SAFE AND EFFICIENT IN PATIENTS WITH SYSTEMIC AUTOIMMUNE MYOPATHIES
    (2021) SOUSA, L. F. Adsuara de; MISSE, R. G.; SANTOS, L. De Macedo Dos; BAPTISTA, A. Fontes; TANAKA, C.; GREVE, J. M. D'andrea; SHINJO, S. Katsuyuki
  • article 2 Citação(ões) na Scopus
    Noninvasive Neuromodulation Techniques in Difficult Tracheostomy Weaning of Patients With Spinal Cord Injury Report of Two Cases
    (2021) CARVALHO, Priscila De; GOULARDINS, Juliana Barbosa; SOUSA, Danilo Miyoji Nakamura de; BARBOSA, Cristiane Marcela da Silva; CAETANO, Thabata Cristina Candido; SANTOS, Lucas de Macedo dos; ITO, Clara Hikari; HIROTA, Adriana Sayuri; PEREIRA, Rita Pavione Rodrigues; BAPTISTA, Abrahao Fontes; TANAKA, Clarice
    High spinal cord injured patients (SCI) are susceptible to respiratory muscle impairments. Transcranial direct current stimulation (tDCS) and peripheral electrical stimulation (PES) may influence the diaphragm's central control, but until now they are not described as a therapeutic resource for difficult weaning. We present two case reports of SCI patients (P1 and P2) with long-term tracheostomy (>40 days) and hospital stay (>50 days). In association with respiratory exercise, P1 received a combined application of anodal tDCS over the supplementary motor area plus sensory PES in the thoracic-abdominal muscles, and P2 received isolated excitatory PES in the abdominal muscles, applied daily except on weekends. Maximum inspiratory/expiratory pressure, peak cough flow, diaphragm excursion, and thickening fraction were measured in the first and last days of the protocol. Both patients had improvements, with clinical impact such as cough effectiveness, decannulated after 15 applications of stimulation. Augmentation of neural respiratory drive and corticospinal excitability is suggested.
  • conferenceObject
    Transcranial direct current stimulation and cough effectiveness in SCI patients: case report
    (2020) CARVALHO, Priscila de; HIROTA, Adriana Sayuri; SANT'ANNA, Guadalupe Nery; GOULARDINS, Juliana Barbosa; SANTOS, Lucas Macedo; CAETANO, Thabata; ITO, Clara Hikari; MOL, Caroline Gomes; RODRIGUES, Rita Pavione; BAPTISTA, Abrahao Fontes; TANAKA, Clarice