LILIAN KELLY FARIA LICARIAO ROCHA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- Circumscribed palmoplantar hypokeratosis: report of two Brazilian cases(2013) ROCHA, Lilian Kelly; NICO, Marcello Menta SimonsenCircumscribed palmoplantar hypokeratosis is a recently recognized dermatosis and rarely reported. It was first described in 2002 and is characterized by localized loss of the horny layer in the palmoplantar area. This dermatosis is clinically presented with a sharply circumscribed, reddish and asymptomatic plaque with slightly depressed surface localized on the palms or the soles. The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease. Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area. We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis. We also present a brief literature review of the etiopathogenic hyphoteses of this dermatosis.
- Confocal microscopy, dermoscopy, and histopathology features of atypical intraepidermal melanocytic proliferations associated with evolution to melanoma in situ(2022) ROCHA, Lilian K. F. L.; VILAIN, Ricardo E.; SCOLYER, Richard A.; LO, Serine N.; DRUMMOND, Martin; STAR, Phoebe; FOGARTY, Gerald B.; HONG, Angela M.; GUITERA, PascaleBackground Atypical intraepidermal melanocytic proliferations (AIMP) is a descriptive term sometimes applied to biopsies that do not fulfill diagnostic criteria of melanoma. They are common on sun-damaged skin, but their definition and management are controversial. Objective To describe dermoscopic (DS), reflectance confocal microscopic (RCM) and histopathological features of AIMP and identify features associated with subsequent melanoma in situ (MIS). Methods A retrospective analysis of AIMP lesions correlated with patient outcome at two melanoma tertiary centers between 2005 and 2015. Results Thirty-four patients were included. Nine (26%) patients had MIS in subsequent biopsies. Predictors of later MIS were target-like pattern (OR:12.0 [CI: 1.23, 117.41]; P = 0.032) and high-density vascular network (OR:12 [CI: 1.23-117.41], P: 0.032) on DS, and presence of dendritic cells touching each other (OR:9.1 [CI: 1.54, 54.59], P = 0.014) on RCM. Clinical predictors of worse outcome included a previous history of MIS at the same site. Radiotherapy for AIMP had a high failure rate (all patients presented with recurrent disease, three as AIMP and two as MIS). Conclusions Considering that most cases in this series received non-surgical treatment at baseline, we recommend close monitoring for lesions with target-like pattern and density vascular network on DS and treatment for lesions with progression of atypia and/or with ""confluent"" dendritic cells on RCM. Although the number of patients in this series is very low, early surgery is recommended for MIS cases that recur as AIMP.
- Reflectance confocal microscopy (RCM)-based criteria for progression of lower-lip squamous cell carcinoma: A prospective study(2022) FERREIRA, Paula Silva; ROCHA, Lilian; BEZERRA, Ana Patricia Carneiro; NICO, Marcello Menta Simonsen; LOURENCO, Silvia VanessaBackground: Actinic cheilitis (AC) presents as a diffuse clinical-histopathological alteration throughout the lower lip. Objectives: To analyze AC lesions using reflectance confocal microscopy (RCM) and evaluate criteria for the early diagnosis of incipient squamous cell carcinoma (SCC). Methods: This prospective study comprised cases of clinically diagnosed AC. RCM was performed over the entire extension of the lower lip. The sites that showed the highest degree of morphological alteration by RCM, according to established criteria for AC and SCC, were biopsied. The RCM findings and histopathology were correlated to establish the precise and early diagnosis of SCC. Results: A total of 61 cases that had been clinically diagnosed with AC were included. The RCM findings that correlated independently with SCC were: nonedged papillae (sensitivity 84% and specificity 88%, p < 0.0001, and OR 42), cell-filled papillae (sensitivity 82% and specificity 93%, p < 0.0001, and OR 71.3), inflammation (sensitivity 68% and specificity 68%, p = 0.0163, and OR 4.8), large and roundish cells in the lamina propria (sensitivity 65% and specificity 100%, p < 0.0001, and OR infinity), and nests in the lamina propria (sensitivity 54% and specificity 100%, p < 0.0001, and OR infinity). An independent histopathological analysis classified the cases as partial epithelial dysplasia (25 cases, 41%) and SCC (36, 59%), and in 57 cases (94%), the results agreed with the categorization that was rendered by the RCM exam. Conclusions: RCM can be used to monitor AC cases, guide the biopsy site, and identify the early progression of AC to SCC with good sensitivity and specificity.
- Reflectance confocal microscopy - Consensus terminology glossary in Brazilian Portuguese for normal skin, melanocytic and non-melanocytic lesions(2024) BRAGA, Juliana Casagrande Tavoloni; BARCAUI, Carlos B.; PINHEIRO, Ana Maria; SORTINO, Ana Maria Fagundes; ABDALLA, Cristina Martinez Zugaib; CAMPOS-DO-CARMO, Gabriella; REZZE, Gisele Gargantini; PINEIRO-MACEIRA, Juan; ROCHA, Lilian Licariao; MAIA, Marcus; SA, Bianca Costa Soares deBackground: Currently, there is no uniform and official terminology in Portuguese for reflectance confocal microscopy analysis, despite the increasing number of Brazilian dermatologists using this new tool. Objective: To present the terminology in Brazilian Portuguese for the description of reflectance confocal microscopy and establish the first Brazilian consensus on terms related to normal skin and cutaneous tumors. Methods: 10 Brazilian specialists from different institutions and states of Brazil were selected to evaluate the best corresponding terms in Portuguese for normal skin, melanocytic and nonmelanocytic tumors. The terms used were translated from international consensuses in the English language. The modified Delphi method was used to create the consensus in 3 steps. Results: The terms considered the most appropriate in the Portuguese language to describe the findings of normal skin, melanocytic and non-melanocytic lesions in the reflectance confocal microscopy analysis were presented. Study limitations: The limitations of the present study include the number of participants and limited regional representation (only two of the five Brazilian regions were represented). Conclusion: This Brazilian consensus represents an opportunity for dermatologists and physicians specializing in cutaneous oncology to become familiar with reflectance confocal microscopy, propagating the technique in clinical and research environments to stimulate national and international publications on this subject.
conferenceObject Analysis of an electrical impedance spectroscopy system in short-term digital dermoscopy imaging of melanocytic lesions(2016) ROCHA, L.; GUITERA, P.; KHOURY, R.; AVRAMIDIS, M.; LO, S.; MENZIES, S.- Imiquimod chemoprophylaxis for field cancerization in xeroderma pigmentosum patients-A prospective study(2023) ROCHA, Lilian Kelly Faria Licariao; FERREIRA, Paula; GIANOTTI, Marcelo A.; AVANCINI, Joao; MENCK, Carlos F. M.; CASTRO, Ligia P.; OLIVEIRA, Zilda Najjar Prado de; RIVITTI, Maria C.; SAMORANO, Luciana P.; PEREIRA, Naiura Vieira; FESTA NETO, Cyro
- Cutaneous Manifestations and Comorbidities in 60 Cases of Takayasu Arteritis (vol 40, pg 734, 2013)(2013) ROCHA, K. L.; ROMITTI, R.; SHINJO, S.; NETO, M. L.; CARVALHO, J.; CRIADO, Paulo Ricardo
- Dermoscopic features of 61 skin lesions in xeroderma pigmentosum patients: A cross-sectional study(2022) ROCHA, Lilian Kelly Faria Licariao; FERREIRA, Paula; AVANCINI, Joao; CASTRO, Ligia P.; NAJJAR, Zilda; RIVITTI-MACHADO, Maria C.; SAMORANO, Luciana Paula; BARBOSA, Caroline F.; COLACIQUE, Caroline; FESTA-NETO, Cyro
- Cutaneous Manifestations and Comorbidities in 60 Cases of Takayasu Arteritis(2013) ROCHA, Lilian Kelly; ROMITTI, Ricardo; SHINJO, Samuel; NETO, Mauricio Levy; CARVALHO, Jozelio; CRIADO, Paulo