EDUARDO MASSAD
Projetos de Pesquisa
Unidades Organizacionais
Departamento de MedicinaLegal, Ética Médica e Medicina Social e do Trabalho, Faculdade de Medicina - Docente
LIM/01 - Laboratório de Informática Médica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/01 - Laboratório de Informática Médica, Hospital das Clínicas, Faculdade de Medicina - Líder
55 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 55
- Cost-effectiveness analysis of diagnostics tests of respiratory tract infection in cancer patients(2016) FURLAN, Teresa; MASSAD, Eduardo
- Potential exposure to Zika virus for foreign tourists during the 2016 Carnival and Olympic Games in Rio de Janeiro, Brazil(2016) BURATTINI, M. N.; COUTINHO, F. A. B.; LOPEZ, L. F.; XIMENES, R.; QUAM, M.; WILDER-SMITH, A.; MASSAD, E.
- Modeling criminal careers of different levels of offence(2023) RAIMUNDO, Silvia Martorano; YANG, Hyun Mo; RUBIO, Felipe Alves; GREENHALGH, David; MASSAD, EduardoWe set up and analyse a mathematical model, the Serious Crime Model, which describes the interaction of mild and serious offenders and potential criminals. However we get more complete results for a simpler version of this model, the Mild Crime Model, with no serious offenders. For the full Serious Crime Model there are two key parameters R 10 and R 20 corresponding to the basic reproduction number in the mathematics of infectious diseases, which determine the behaviour of the system. For the Simpler Mild Crime Model there is just one such parameter R 10 . Both forward and backward bifurcation can occur for this second model with two subcritical non-trivial equilibria possible for R 10 < 1 in the backwards case. For backwards bifurcation there is another threshold value R*0 such that the upper non-trivial equilibrium is unstable for R 10 < R*0 and stable for R 10 > R*0. For for-wards bifurcation there is a second additional threshold value R 0** such that the stability of the unique non-trivial equilibrium switches from unstable to stable as R 10 passes through R ** 0 . At the end we return to the full Serious Crime Model and discuss the behaviour of this model. The results are meaningful and interesting because in all of the other epidemiolog-ical and sociological models of which we are aware, analogous thresholds to R*0 and R ** 0 do not exist. For forwards bifurcation the unique non-trivial equilibrium, and for backwards bifurcation with two subcritical endemic equilibria the higher non-trivial equilibrium, are also usually always locally asymptotically stable. So our models exhibit unusual and inter-esting behaviour.(c) 2023 The Authors.
conferenceObject Madeira's dengue outbreak in 2012: could it happen again in the near future?(2015) QUAM, M. B.; HELMERSSON, J. L.; MASSAD, E.; WILDER-SMITH, A.; ROCKL, J.- The cost of dengue control(2011) MASSAD, Eduardo; COUTINHO, Francisco Antonio Bezerra
- The optimal age of vaccination against dengue in Brazil based on serotype-specific forces of infection derived from serological data(2021) MAIER, Sandra B.; MASSAD, Eduardo; AMAKU, Marcos; BURATTINI, Marcelo N.; GREENHALGH, DavidIn this paper, we study a single serotype transmission model of dengue to determine the optimal vaccination age for Dengvaxia. The transmission dynamics are modelled with an age-dependent force of infection. The force of infection for each serotype is derived from the serological profile of dengue in Brazil without serotype distinction and from serotype-specific reported cases. The risk due to an infection is measured by the probability of requiring hospitalization based on Brazilian Ministry of Health data. The optimal vaccination age is determined for any number and combination of the four distinct dengue virus serotypes DENv1-4. The lifetime expected risk is adapted to include antibody dependent enhancement (ADE) and permanent cross-immunity after two heterologous infections. The risk is assumed to be serostatus-dependent. The optimal vaccination age is computed for constant, serostatus-specific vaccine efficacies. Additionally, the vaccination age is restricted to conform to the licence of Dengvaxia in Brazil and the achievable and minimal lifetime expected risks are compared. The optimal vaccination age obtained for the risk of hospitalization varies significantly with the assumptions relating to ADE and cross-immunity. Risk-free primary infections lead to higher optimal vaccination ages, as do asymptomatic third and fourth infections. Sometimes vaccination is not recommended at all, e.g. for any endemic area with a single serotype if primary infections are risk-free. Restricting the vaccination age to Dengvaxia licensed ages mostly leads to only a slightly higher lifetime expected risk and the vaccine should be administered as close as possible to the optimal vaccination age.
- Differences in Placental Histology Between Zika Virus-infected Teenagers and Older Women(2022) SANTOS, Geovane R.; PINTO, Clovis A. L.; PRUDENTE, Raphael C. S.; WITKIN, Steven S.; ARANDES, Antoni S.; RODRIGUES, Laura C.; ZATZ, Mayana; MASSAD, Eduardo; PASSOS, Saulo D.In pregnant women, Zika virus (ZIKV) is associated with a congenital syndrome, most frequently involving damage to embryo brain formation and the development of microcephaly. The mechanism(s) by which ZIKV enters the maternal-fetal interface and is transmitted to the fetus remains incompletely determined. We sought to evaluate histologic changes in the placenta of ZIKV-infected pregnant women and to determine if this varied by maternal age. Placental samples were obtained from 66 women, 33 of whom were positive for ZIKV. Histologic evaluations were performed on 4 areas of the placenta: fetal surface, maternal surface, umbilical cord, and membranes. Samples were analyzed by the tissue microarray technique and tested for CD4, CD8, CD20, CD68, FOXP3, and cyclooxygenase-2 expression. Data were evaluated using Fisher exact test. ZIKV infection was more frequent in women less than 18 yr of age (9/11, 81.8%) than in women above 18 yr old (24/55, 43.6%) (P=0.0440). ZIKV detection was associated with neutrophilic chorioamnionitis (P=0.0332) and with septal (P=0.0244) and villous (P=0.0534) calcification. Hofbauer cell hyperplasia (P=0.0260) and cyclooxygenase-2 expression (P=0.0346) were more prevalent in ZIKV-positive women aged 18 yr and below than in the older ZIKV-positive women. ZIKV infection during pregnancy occurs more frequently in adolescents and induces higher rates of damage at the maternal-fetal interface than in older women.
conferenceObject The risk of infectious diseases introduction into non-infected countries by travelers visiting endemic countries(2015) MASSAD, E.; LOPEZ, L. F.; AMAKU, M.; COUTINHO, F. A. B.; QUAM, M.; BURATTINI, M. N.; STRUCHINER, C. J.; WILDER-SMITH, A.conferenceObject Seasonality of dengue epidemic potential in Europe - based on vectorial capacity for Aedes mosquitoes(2015) HELMERSSON, J. L.; QUAM, M.; STENLUND, H.; WILDER-SMITH, A.; EBI, K.; MASSAD, E.; ROCKLOV, J.- Fuzzy cognitive map in differential diagnosis of alterations in urinary elimination: A nursing approach(2013) LOPES, Maria Helena Baena de Moraes; ORTEGA, Neli Regina Siqueira; SILVEIRA, Paulo Sergio Panse; MASSAD, Eduardo; HIGA, Rosangela; MARIN, Heimar de FatimaPurpose: To develop a decision support system to discriminate the diagnoses of alterations in urinary elimination, according to the nursing terminology of NANDA International (NANDA-I). Methods: A fuzzy cognitive map (FCM) was structured considering six possible diagnoses: stress urinary incontinence, reflex urinary incontinence, urge urinary incontinence, functional urinary incontinence, total urinary incontinence and urinary retention; and 39 signals associated with them. The model was implemented in Microsoft Visual C++(R) Edition 2005 and applied in 195 real cases. Its performance was evaluated through the agreement test, comparing its results with the diagnoses determined by three experts (nurses). The sensitivity and specificity of the model were calculated considering the expert's opinion as a gold standard. In order to compute the Kappa's values we considered two situations, since more than one diagnosis was possible: the overestimation of the accordance in which the case was considered as concordant when at least one diagnoses was equal; and the underestimation of the accordance, in which the case was considered as discordant when at least one diagnosis was different. Results: The overestimation of the accordance showed an excellent agreement (kappa = 0.92, p < 0.0001); and the underestimation provided a moderate agreement (kappa = 0.42, p < 0.0001). In general the FCM model showed high sensitivity and specificity, of 0.95 and 0.92, respectively, but provided a low specificity value in determining the diagnosis of urge urinary incontinence (0.43) and a low sensitivity value to total urinary incontinence (0.42). Conclusions: The decision support system developed presented a good performance compared to other types of expert systems for differential diagnosis of alterations in urinary elimination. Since there are few similar studies in the literature, we are convinced of the importance of investing in this kind of modeling, both from the theoretical and from the health applied points of view. Limitations: In spite of the good results, the FCM should be improved to identify the diagnoses of urge urinary incontinence and total urinary incontinence.