DULCE REIS GUARITA
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bookPart Doenças Pancreáticas(2016) GUARITA, Dulce Reis; FELGA, Guilherme Eduardo Gonçalves; MARZINOTTO, Maira Andrade Nacimbem; TEIXEIRA, Ana Cristina de Sá; PEDROSO, Martha Regina Arcon; MOTT, Carlos de BarrosbookPart Neoplasias Pancreáticas(2016) FELGA, Guilherme Eduardo Gonçalves; GUARITA, Dulce Reis; CUNHA, José Eduardo Monteiro da; ROCHA, Manoel de Souza- COMPARISON OF FECAL ELASTASE 1 FOR EXOCRINE PANCREATIC INSUFFICIENCY EVALUATION BETWEEN EX-ALCOHOLICS AND CHRONIC PANCREATITIS PATIENTS(2014) MATTAR, Rejane; LIMA, Gustavo André Silva; COSTA, Marianges Zadrozny Gouvêa da; SILVA-ETTO, Joyce M Kinoshita; GUARITA, Dulce; CARRILHO, Flair JoséContext Fecal elastase is a noninvasive test for pancreatic insufficiency diagnosis. Objectives Evaluate the usefulness of fecal elastase 1 for the indication of exocrine pancreatic insufficiency among former alcohol addicts and patients with chronic pancreatitis. Methods Forty-three patients with chronic pancreatitis and thirty-three asymptomatic former alcohol addicts entered the study. The levels of fecal elastase 1 were measured using a commercial kit. Pancreatic imaging findings were used to categorize the groups. Results The levels of fecal elastase 1 were significantly lower in the patients than in the former alcohol addicts and in the group with tissue calcifications, duct alterations, or atrophy. With a cutoff level of 100 μg/g, the sensitivity of fecal elastase 1 in chronic pancreatitis was 46.51% and its specificity was 87.88% with a positive predictive value of 83.33% and a negative predictive value of 55.77%. When patients were stratified according to the severity of their pancreatitis, the sensitivity was 6.25% for mild pancreatitis and 70.37% for marked pancreatitis. Conclusion Low level of fecal elastase 1 was associated with marked rather than mild chronic pancreatitis; however, it may be useful to indicate pancreatic exocrine insufficiency in asymptomatic former alcohol addicts.
bookPart Provas de função pancreática(2013) FELGA, Guilherme E. G.; COSTA, Marianges Zadrozny Gouvêa da; GUARITA, Dulce Reis- Genetic Risk for Alcoholic Chronic Pancreatitis(2011) COSTA, Marianges Zadrozny Gouvea da; GUARITA, Dulce Reis; ONO-NITA, Suzane Kioko; PARANAGUA-VEZOZZO, Denise Cerqueira; FELGA, Guilherme Eduardo Goncalves; PEDROSO, Martha Regina Arcon; SOUZA, Marcelo Moreira Tavares de; NASSER, Paulo Dominguez; FERREIRA, Camila da Silva; CARRILHO, Flair JoseIn recent years many studies have examined the genetic predisposition to pancreatic diseases. Pancreatic disease of an alcoholic etiology was determined to be a multi-factorial disease, where environmental factors interact with the genetic profile of the individual. In this review we discuss the main results from studies examining the frequency of genetic mutations in alcoholic chronic pancreatitis.