SILVANA CEREIJIDO ALTRAN
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/04 - Laboratório de Microcirurgia, Hospital das Clínicas, Faculdade de Medicina
LIM/04 - Laboratório de Microcirurgia, Hospital das Clínicas, Faculdade de Medicina
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- Terapias compressivas no tratamento de úlcera venosa: estudo bibliométrico(2015) TEIXEIRA NICOLOSI, Júlia; CEREIJIDO ALTRAN, Silvana; PIRO BARRAGAM, Jéssica; FERNANDES DE CARVALHO, Viviane; ISSAC, CésarIntroduction: Venous ulcers are skin lesions, which usually affect the lower third of the legs. The treatment of these wounds is dynamic and depends on the tissue repair process. Clinical and surgical procedures are included among those therapies, and the therapeutic compressive most often used non-surgical method. Inelastic and elastic bandages, elastic stockings and intermittent pneumatic pressure are the most common compressive therapy used. Objective: This study aimed to identify the national and international scientific literature profile describing compression therapy and venous ulcers and classify that profile according to: chronology of publication, country, periodicals that are published review of 'Qualis' - CAPES, distribution of the methodological approach, analysis of the publications content and compare, where possible, the data presented. Method: bibliometric study conducted in the Medline, Lilacs and CINAHL databases using the keywords ""Varicose Ulcer / therapy"", ""Compression Bandages"", ""Wound Healing"" and boleyn word AND between the years 2009-2013. Results: 47 articles were selected, the major part was published in 2012 (n = 12, 25.53 %), the United States (n = 14, 29.78 %) and the United Kingdom (n = 14, 29.78%), in vascular surgery specialized magazines (n = 19, 40.42%), Qualis A2 (n = 13, 27.65 %) and B1 (n = 13, 27.65 %). Much of the methodology used in the selected studies was ""clinical studies"" type (n = 30, 63.82 %). Only 30 % ( n = 14 ) had as main objective assessment of compressive therapy and intended study compared the effectiveness of elastic bandages, inelastic, elastic stockings , intermittent pneumatic pressure and absence compression therapy for the treatment of venous ulcers. Conclusions: There is a concern, in the scientific community, about the research for effective treatment for venous ulcers. However, the worldwide distribution of publications is uneven. It was evident that compression therapy is not the main object in the majority of selected studies emerging interest in adjuvant or complementary to such therapies. It is evident the compressive therapy need, but there is no consensus on which pressure should be used for best results in healing and more studies must be performed to evaluate the interference of different pressures levels on the tissue repair process . There is also a lack of studies demonstrating the action of intermittent pneumatic pressure or not associations with elastic bandages
- Adipose tissue-derived stem cells as a therapeutic strategy for enterocutaneous fistula: an experimental model study(2023) PAGOTTO, Vitor Penteado Figueiredo; CAMARGO, Cristina Pires; CACERES, Paula Vitoria; ALTRAN, Silvana Cereijido; GEMPERLI, RolfPurpose: Enterocutaneous fistula (ECF) is a condition in which there is an abnormal connection between the intestinal tract and the skin. It can lead to high morbidity and mortality rates despite the availability of therapeutic options. Stem cells have emerged as a potential strategy to treat ECF. This study aimed to evaluate the effect of adipose tissue-derived stem cells (ASC) on ECF in an experimental model. Methods: ECF was induced in 21 Wistar rats, and after one month, they were divided into three groups: control group (C), culture medium without ASC group (CM), and allogeneic ASC group (ASC). After 30 days, the animals underwent macroscopic analysis of ECF diameter and histopathological analysis of inflammatory cells, tissue fibrosis, and vascular density. Results: The study found a 55% decrease in the ECF diameter in the ASC group (4.5 +/- 1.4 mm) compared to the control group (10.0 +/- 2.1 mm, p = 0.001) and a 59.1% decrease in the CM group (11.0 +/- 4.3 mm, p = 0.003). The fibrosis score in the ASC group was 20.9% lower than the control group (p = 0.03). There were no significant differences in inflammation scores among the three groups. Conclusion: This study suggests that ASC treatment can reduce ECF diameter, and reduction in tissue fibrosis may be a related mechanism. Further studies are needed to understand the underlying mechanisms fully.