VINICIUS LACERDA RIBEIRO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- High-risk human papillomavirus test in anal smears: can it optimize the screening for anal cancer?(2021) KIMURA, Cintia M. S.; NAHAS, Caio S. R.; V, Edesio Silva-Filho; RIBEIRO, Vinicius L.; SEGURADO, Aluisio C.; ALCANTARA, Flavio F. P.; CECCONELLO, Ivan; NAHAS, Sergio C.Objective: The current method for screening anal cancer is anal cytology, which has low sensitivity. Since high-risk human papillomavirus (HR-HPV) is associated with almost 90% of cases of anal cancer, the objective of this study is to evaluate whether testing for HR-HPV can optimize the screening. Design: Prospective study with patients enrolled in a screening program for anal dysplasia. Considering high-resolution anoscopy (HRA)-guided biopsy as the gold standard for diagnosis of high-grade squamous intraepithelial lesions, the diagnostic performance of anal cytology, HR-HPV testing, and the combination of both was calculated. Settings: A single center for anal dysplasia. Participants: A total of 364 patients (72% males, 82% HIV-positive). Intervention: Patients underwent anal cytology, HR-HPV test, and HRA-guided biopsy of the anal canal. Main outcome measures: Ability of cytology and HR-HPV test (individually and combined) to detect high-grade squamous intraepithelial lesions, and analysis of the cost of each diagnostic algorithm. Results: Cytology alone was the cheapest approach, but had the lowest sensitivity [59%, 95% confidence interval (CI) 46-71%], despite of highest specificity (73%, 95% CI 68-78%). Cotesting had the highest sensitivity (85%, 95% CI 74-93%) and lowest specificity (43%, 95% CI 38-49%), and did not seem to be cost-effective. However, HR-HPV testing can be used to triage patients with normal and atypical squamous cells of undetermined significance cytology for HRA, resulting in an algorithm with high sensitivity (80%, 95% CI 68-89%), and specificity (71%, 95% CI 65-76%), allied to a good cost-effectiveness. Conclusion: HR-HPV testing is helpful to optimize the screening in cases of normal and atypical squamous cells of undetermined significance cytology.
conferenceObject 2020 CHICAGO SOCIETY OF COLON & RECTAL SURGEONS DURAND SMITH, MD, AWARD HIGH-RISK HPV TESTING IN ANAL PAP SMEAR: CAN IT OPTIMIZE THE SCREENING FOR ANAL CANCER?(2021) KIMURA, C. M.; NAHAS, C. R.; SILVA FILHO, E. Vieira da; RIBEIRO, V. Lacerda; ALCANTARA, F. Ferraz de Paes; PAIVA, A. Mendes; CECCONELLO, I.; NAHAS, S. C.conferenceObject HIGH-RISK HPV TESTING IN ANAL PAP SMEAR: CAN IT OPTIMIZE THE SCREENING FOR ANAL CANCER?(2020) KIMURA, C. M.; NAHAS, C. R.; SILVA FILHO, E. Vieira da; RIBEIRO, V. Lacerda; ALCANTARA, F. Ferraz de Paes; PAIVA, A. Mendes; NAHAS, S. C.; CECCONELLO, I.