NIDIA DENISE PUCCI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
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bookPart Aspectos nutricionais da litíase urinária(2014) PUCCI, Nidia DenisebookPart Roteiro de Dietas na Clínica Cirúrgica(2013) PUCCI, Nidia Denise; CORRêA, Luciana Solino- Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention(2018) PUCCI, Nidia D.; MARCHINI, Giovanni S.; MAZZUCCHI, Eduardo; REIS, Sabrina T.; SROUGI, Miguel; EVAZIAN, Denise; NAHAS, William C.Phyllanthus niruri (P.niruri) or stone breaker is a plant commonly used to reduce stone risk, however, clinical studies on this issue are lacking. Objective: To prospectively evaluate the effect of P. niruri on the urinary metabolic parameters of patients with urinary lithiasis. Materials and Methods: We studied 56 patients with kidney stones < 10mm. Clinical, metabolic, and ultrasonography assessment was conducted before (baseline) the use of P. niruri infusion for 12-weeks (P. niruri) and after a 12-week (wash out) Statistical analysis included ANOVA for repeated measures and Tukey's/McNemar's test for categorical variables. Significance was set at 5%. Results: Mean age was 44 +/- 9.2 and BMI was 27.2 +/- 4.4kg/m2. Thirty-six patients (64%) were women. There were no significant changes in all periods for anthropometric and several serum measurements, including total blood count, creatinine, uric acid, sodium, potassium, calcium, urine volume and pH; a significant increase in urinary potassium from 50.5 +/- 20.4 to 56.2 +/- 21.8 mg/24-hour (p=0.017); magnesium/creatinine ratio 58 +/- 22.5 to 69.1 +/- 28.6mg/gCr24-hour (p=0.013) and potassium/creatinine ratio 39.3 +/- 15.1 to 51.3 +/- 34.7mg/gCr24hour (p=0.008) from baseline to wash out. The kidney stones decreased from 3.2 +/- 2 to 2.0 +/- 2per patient (p<0.001). In hyperoxaluria patients, urinary oxalate reduced from 59.0 +/- 11.7 to 28.8 +/- 16.0mg/24-hour (p=0.0002), and in hyperuricosuria there was a decrease in urinary uric acid from 0.77 +/- 0.22 to 0.54 +/- 0.07mg/24-hour (p=0.0057). Conclusions: P. niruri intake is safe and does not cause significant adverse effects on serum metabolic parameters. It increases urinary excretion of magnesium and potassium caused a significant decrease in urinary oxalate and uric acid in patients with hyperoxaluria and hyperuricosuria. The consumption of P. niruri contributed to the elimination of urinary calculi.
bookPart Necessidades Nutricionais em Pessoas Saudáveis(2016) PUCCI, Nidia Denise; MENEZES, Fernanda Lourenço de; DAMIãO, Adérson Omar Mourão Cintra- Effect of a low-calorie diet on 24-hour urinary parameters of obese adults with idiopathic calcium oxalate kidney stones(2021) DANILOVIC, Alexandre; MARCHINI, Giovanni Scala; PUCCI, Nidia Denise; COIMBRA, Brian; TORRICELLI, Fabio Cesar Miranda; BATAGELLO, Carlos; VICENTINI, Fabio Carvalho; SROUGI, Miguel; NAHAS, William C.; MAZZUCCHI, EduardoPurpose: to evaluate the effect of low-calorie diet on 24-hour urinary metabolic parameters of obese adults with idiopathic calcium oxalate kidney stones. Materials and Methods: Adult idiopathic calcium oxalate stone formers, with body mass index (BMI) >= 30kg/m(2) and a known lithogenic metabolic abnormality, were submitted to low-calorie diet for twelve weeks. After enrolment, anthropometric measures, serum exams, 24-hour urinary metabolic parameters and body impedance were collected one month prior to dietary intervention and at the end of twelve weeks. Correlations between weight loss, waist circumference loss, fat loss and variation in 24-hour urinary lithogenic parameters and calcium oxalate urinary supersaturation (CaOx SS) as per Tiselius equation were analysed. Results: From January 2017 to January 2018, 39 patients were enrolled to participate in this study. Median (range) prescribed diet was 1300 (1100-2100) Kcal/day. Mean age was 51.7 +/- 11.0 (29-68) years old and 69.2% were female. 30.8% of the participants shifted from obesity to BMI <30kg/m(2) and none to BMI <25kg/m(2). A significant correlation was found between baseline 24-hour urinary oxalate and weight (p=0.018) and BMI (p=0.026). No correlation was found between variation of weight, waist circumference, fat mass and 24-h urinary stone risk factors or CaOx SS. Conclusions: Short-term modest weight loss induced by twelve weeks of low-calorie diet is not associated with a decrease of 24-hour urinary lithogenic parameters in idiopathic calcium oxalate stone formers. Calcium oxalate urinary stone formation is probably multifactorial and driven by other factors than weight.
bookPart Aspectos Nutricionais(2016) NOMURA, Roseli Mieko Yamamoto; PUCCI, Nidia DenisebookPart Epidemiologia da litíase Urinária(2014) MARCHINI, Giovanni Scala; DANILOVIC, Alexandre; PUCCI, Nidia Denise