LUAN HENRIQUE VASCONCELOS ALVES

(Fonte: Lattes)
Índice h a partir de 2011
1
Lattes
Projetos de Pesquisa
Unidades Organizacionais
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

Resultados de Busca

Agora exibindo 1 - 3 de 3
  • article 1 Citação(ões) na Scopus
    Increased bone resorption by long-term cigarette smoke exposure in animal model
    (2021) JUNQUEIRA, Jader Joel Machado; LOURENCO, Juliana Dias; SILVA, Kaique Rodrigues da; JORGETTI, Vanda; VIEIRA, Rodolfo P.; ARAUJO, Amanda Aparecida de; ANGELIS, Katia De; CORREIA, Aristides Tadeu; ALVES, Luan Henrique Vasconcelos; TIBERIO, Iolanda de Fatima Lopes Calvo; BARBOSA, Alexandre Povoa; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos
    Introduction: Clinical and experimental studies have been attesting the deleterious effects of smoking mainly due to the stimulation of osteoclastogenesis and inhibition of osteoblastogenesis. However the physiological mechanisms that can explain these changes are not fully understood. Aims: To evaluate the trabecular bone resorption effect caused by long-term exposure to cigarette smoke and the action of cytokines and reactive oxygen species involved in this process. Methods: Sixty young adult C57BL/6 mice were allocated to two groups: control, 30 animals exposed to filtered air for 1, 3 and 6 months; and smoke, 30 animals exposed to cigarette smoke for 1, 3 and 6 months. Femoral and tibial extraction was performed to evaluate the bone mineral matrix, bone cytokines (Receptor activator of nuclear factor-kappa B ligand -RANKL and Osteoprotegerin -OPG) and oxidative stress markers (Thiobarbituric acid reactive substances -Tbars). Results: Exposure to cigarette smoke (CS) generated changes in bone structural parameters in the 6th month of follow-up, demonstrating an evident bone loss; reduction in OPG/RANKL ratio from the 3rd month on and increase in Tbars in the first month, both closely related to the increase in osteoclastogenic activity and bone resorption. Conclusion: These findings reinforce the importance of CS-induced oxidative stress in bone compromising the bone cellular activities with a consequent impairment in bone turn over and changes in bone structure.
  • conferenceObject
    Effect of exercise training on Treg cell response in severe COPD individuals: a randomized and controlled trial
    (2022) ITO, J. T.; OLIVEIRA, L. M.; V, L. Alves; XAVIER, R. F.; SATO, M. N.; CARVALHO, C. R. F.; TIBERIO, I. F. L. C.; LOPES, F. D. T. Q. S.
  • conferenceObject
    The imbalance between subpopulations of regulatory T (TREG) Cells at different stages of chronic obstructive pulmonary disease (COPD)
    (2023) ALVES, Luan Henrique Vasconcelos; A, Juliana Tiyaki Ito; OLIVEIRA, Luana Mendonca De; TIBERIO, Iolanda Lopes Calvo; STELMACH, Rafael; SATO, Maria Notomi; ALMEIDA, Francine Maria; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos